Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | GLS | O94925 | 1/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5495469 | 0.90 | CYP19A1 (0.54) | CYP19A1TBXAS1KDM4EMAPTMEN1 | |
| SCHEMBL428159 | 0.83 | MAPT (0.58) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL14127412 | 0.83 | MAPT (0.58) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL29662059 | 0.83 | MAPT (0.58) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL6880778 | 0.80 | CYP19A1 (0.51) | CYP19A1TBXAS1KDM4EMAPTMEN1 | |
| SCHEMBL16415013 | 0.79 | TAAR1 (0.38) | MEN1KMT2A | |
| SCHEMBL6176955 | 0.78 | LOXL2 (0.60) | CYP19A1TBXAS1KDM4EMAPTMEN1 | |
| SCHEMBL3136413 | 0.77 | KDM4E (0.56) | CYP19A1TBXAS1KDM4EMAPTMEN1 | |
| Quinoline SCHEMBL28116882 | 0.74 | CYP3A4 (0.49) | CYP19A1TBXAS1KDM4EMAPTMEN1 | |
| SCHEMBL5537149 | 0.73 | CYP19A1 (0.54) | CYP19A1TBXAS1KDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392280-A4 | ARYLSULFONAMIDE ETHERS, AND METHODS OF USE THEREOF | WARNER LAMBERT CO (US) | 2005-11-30 | — | — | EP | disclosed |
| EP-1392280-A2 | ARYLSULFONAMIDE ETHERS, AND METHODS OF USE THEREOF | Abbott GmbH & Co. KG (DE) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002089749-A2 | ARYLSULFONAMIDE ETHERS, AND METHODS OF USE THEREOF | ABBOTT GMBH & CO.KG (DE) | 2002-11-14 | — | — | WO | disclosed |