Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | CCKBR | P32239 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6181436 | 0.98 | CCKBR (0.41) | TSHRCYP3A4MAPTGFERCCKBR | |
| SCHEMBL6175357 | 0.89 | CCKBR (0.42) | TSHRGFERCCKBRALDH1A1NPSR1 | |
| SCHEMBL6177833 | 0.89 | CYP3A4 (0.42) | TSHRCYP3A4MAPTCCKBR | |
| SCHEMBL6175491 | 0.86 | CYP3A4 (0.46) | TSHRCYP3A4MAPTCCKBR | |
| SCHEMBL6178686 | 0.83 | PREP (0.42) | TSHRGFERNPSR1MEN1KMT2A | |
| SCHEMBL7950790 | 0.82 | CCKBR (0.46) | TSHRCYP3A4MAPTCCKBRKMT2A | |
| SCHEMBL6178571 | 0.81 | CTSK (0.40) | GFERMEN1KMT2APREP | |
| SCHEMBL7965743 | 0.81 | CCKBR (0.49) | TSHRCYP3A4MAPTCCKBR | |
| SCHEMBL6178904 | 0.80 | CCKBR (0.49) | TSHRCYP3A4MAPTCCKBR | |
| SCHEMBL6192423 | 0.79 | CCKBR (0.47) | TSHRCYP3A4MAPTCCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0945445-B9 | 1,5-BENZODIAZEPINE DERIVATIVES | ZERIA PHARM CO LTD (JP) | 2005-12-28 | — | — | EP | disclosed |
| EP-0945445-B1 | 1,5-BENZODIAZEPINE DERIVATIVES | ZERIA PHARM CO LTD (JP) | 2003-09-03 | — | — | EP | disclosed |
| US-6239131-B1 | WHICH HAVE GASTRIN AND/OR CCK-B (CHOLECYSTOKININ-B) RECEPTOR ANTAGONISM, USEFUL AS REMEDIES FOR GASTRIC ULCER AND GASTROINTESTINAL MOVEMENT DISORDER. | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 2001-05-29 | — | — | US | disclosed |
| EP-0945445-A1 | 1,5-BENZODIAZEPINE DERIVATIVES | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 1999-09-29 | — | — | EP | disclosed |