Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKAR | P32238 | 2/20 | 0.44 |
| ▸ | CCKBR | P32239 | 2/20 | 0.44 |
| ▸ | ACE | P12821 | 3/20 | 0.41 |
| ▸ | PREP | P48147 | 2/20 | 0.38 |
| ▸ | NAAA | Q02083 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6178982 | 0.84 | ACE (0.41) | ACEPREPNAAA | |
| SCHEMBL6176498 | 0.83 | CCKBR (0.44) | CCKBR | |
| SCHEMBL6180175 | 0.82 | ACE (0.41) | ACEPREPNAAAABCB11AGTR2 | |
| SCHEMBL6176834 | 0.82 | ACE (0.42) | ACEPREPNAAAABCB11AGTR2 | |
| SCHEMBL6181003 | 0.81 | POLB (0.45) | ACEPREPNAAA | |
| SCHEMBL6179148 | 0.81 | SCN9A (0.47) | PREPNAAA | |
| SCHEMBL6179501 | 0.78 | CCKAR (0.45) | CCKARCCKBR | |
| SCHEMBL7962689 | 0.75 | BRD4 (0.40) | CCKBRPREP | |
| SCHEMBL6178348 | 0.75 | SCN9A (0.47) | CCKARCCKBRACE | |
| SCHEMBL6177308 | 0.75 | PARP1 (0.40) | CCKBRACEPREPNAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0945445-B9 | 1,5-BENZODIAZEPINE DERIVATIVES | ZERIA PHARM CO LTD (JP) | 2005-12-28 | — | — | EP | disclosed |
| EP-0945445-B1 | 1,5-BENZODIAZEPINE DERIVATIVES | ZERIA PHARM CO LTD (JP) | 2003-09-03 | — | — | EP | disclosed |
| US-6239131-B1 | WHICH HAVE GASTRIN AND/OR CCK-B (CHOLECYSTOKININ-B) RECEPTOR ANTAGONISM, USEFUL AS REMEDIES FOR GASTRIC ULCER AND GASTROINTESTINAL MOVEMENT DISORDER. | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 2001-05-29 | — | — | US | disclosed |
| EP-0945445-A1 | 1,5-BENZODIAZEPINE DERIVATIVES | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 1999-09-29 | — | — | EP | disclosed |