Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5801994 | 0.82 | SLC6A4 (0.38) | — | |
| SCHEMBL5802511 | 0.81 | ADRA1A (0.39) | — | |
| SCHEMBL5798860 | 0.72 | PLAU (0.39) | — | |
| SCHEMBL5802586 | 0.69 | ADRA1A (0.32) | — | |
| SCHEMBL1340369 | 0.66 | UBE2N (0.36) | ACHE | |
| SCHEMBL13241438 | 0.64 | ACHE (0.44) | ACHEPDE3BPDE3A | |
| SCHEMBL13241439 | 0.64 | ACHE (0.44) | ACHEPDE3BPDE3A | |
| SCHEMBL18826051 | 0.64 | ADRA2A (0.46) | — | |
| SCHEMBL80428 | 0.64 | ACHE (0.47) | ACHE | |
| SCHEMBL31236154 | 0.64 | ACHE (0.47) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1507767-A1 | 4-SUBSTITUTED IMIDAZOLE-2-THIONES AND IMIDAZOL-2-ONES AS AGONISTS OF THE ALPHA-2B AND ALPHA-2C ADRENERGIC RECEPTORS | Allergan, Inc. (US) | 2005-02-23 | — | — | EP | disclosed |
| WO-2003099795-A1 | 4-SUBSTITUTED IMIDAZOLE-2-THIONES AND IMIDAZOL-2-ONES AS AGONISTS OF THE ALPHA-2B AND ALPHA-2C ADRENERGIC RECEPTORS | ALLERGAN, INC. (US) | 2003-12-04 | — | — | WO | disclosed |