Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.55 |
| ▸ | HTR2A | P28223 | 2/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | DRD5 | P21918 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6179970 | 0.89 | PKM (0.59) | DRD2HTR2AHRH1PKMLMNA | |
| SCHEMBL6181230 | 0.83 | PKM (0.52) | DRD2HTR2AHRH1PKMMAPT | |
| SCHEMBL9528853 | 0.81 | KAT2B (0.60) | DRD2HTR2AHRH1TP53 | |
| SCHEMBL14739433 | 0.81 | CNR1 (0.52) | HTR2APKMMAPTLMNASIGMAR1 | |
| SCHEMBL6181546 | 0.80 | PKM (0.50) | HTR2APKMMAPTLMNAHTR1A | |
| SCHEMBL6184467 | 0.78 | PKM (0.52) | DRD2HTR2APKMHTR1ADRD3 | |
| SCHEMBL5926252 | 0.78 | HTR2A (0.53) | DRD2HTR2AHRH1MAPTLMNA | |
| SCHEMBL9527442 | 0.78 | HTR1A (0.60) | DRD2HTR1APOLBKMT2A | |
| SCHEMBL9527777 | 0.75 | KAT2B (0.57) | DRD2HTR2AHRH1MAPTLMNA | |
| SCHEMBL5926111 | 0.75 | LMNA (0.44) | DRD2HTR2AHRH1PKMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1430034-B1 | SUBSTITUTED ALKYLAMINOPYRIDAZINONE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 2005-02-09 | — | — | EP | disclosed |
| EP-1430034-A1 | SUBSTITUTED ALKYLAMINOPYRIDAZINONE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | Egis Gyogyszergyar Rt. (HU) | 2004-06-23 | — | — | EP | disclosed |
| WO-2003027078-A1 | SUBSTITUTED ALKYLAMINOPYRIDAZINONE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | EGIS Gyógyszergyár Rt. (HU) | 2003-04-03 | — | — | WO | disclosed |