Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NQO2 | P16083 | 2/20 | 0.38 |
| ▸ | MELK | Q14680 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6181289 | 0.83 | P2RX7 (0.43) | P2RX7ALDH1A1KDM4EMELKMAPT | |
| SCHEMBL24769678 | 0.81 | ALDH1A1 (0.43) | PLA2G2AALDH1A1TSHRKDM4EGAA | |
| SCHEMBL30017097 | 0.81 | ALDH1A1 (0.40) | P2RX7PLA2G2AALDH1A1TSHRKDM4E | |
| SCHEMBL24770163 | 0.81 | ALDH1A1 (0.40) | P2RX7PLA2G2AALDH1A1TSHRKDM4E | |
| SCHEMBL4918571 | 0.80 | CYP4F2 (0.39) | PLA2G2AALDH1A1TSHRKDM4EGAA | |
| SCHEMBL4750181 | 0.76 | GAA (0.42) | ALDH1A1TSHRKDM4EGAAMEN1 | |
| SCHEMBL30217866 | 0.74 | KDM4E (0.47) | ALDH1A1TSHRKDM4EGAAMEN1 | |
| SCHEMBL236107 | 0.74 | KDM4E (0.47) | ALDH1A1TSHRKDM4EGAAMEN1 | |
| SCHEMBL31133002 | 0.73 | MRGPRX4 (0.36) | PLA2G2AALDH1A1TSHRGAAMEN1 | |
| SCHEMBL14966057 | 0.73 | PTGES (0.39) | PLA2G2AALDH1A1TSHRKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501805-A1 | SUBSTITUTED PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003095430-A1 | SUBSTITUTED PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2003-11-20 | — | — | WO | disclosed |