Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 4/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3464553 | 0.86 | NPC1 (0.44) | NPC1RAB9AKMT2AMEN1LMNA | |
| SCHEMBL3459037 | 0.67 | ACACB (0.47) | LMNASMN1; SMN2KDM4EALDH1A1TSHR | |
| SCHEMBL28997586 | 0.66 | NPC1 (0.81) | NPC1RAB9ALMNASMN1; SMN2KDM4E | |
| SCHEMBL6203940 | 0.62 | CYP1A2 (0.37) | KMT2A | |
| SCHEMBL9671060 | 0.62 | MAPT (0.59) | NPC1RAB9ALMNASMN1; SMN2KDM4E | |
| SCHEMBL9671063 | 0.62 | MAPT (0.59) | NPC1RAB9ALMNASMN1; SMN2KDM4E | |
| SCHEMBL16971312 | 0.61 | KDM4E (0.66) | NPC1RAB9AKMT2AMEN1LMNA | |
| SCHEMBL6620194 | 0.60 | CYP1A2 (0.37) | KMT2AMEN1KDM4EALDH1A1TSHR | |
| SCHEMBL7349348 | 0.60 | LMNA (0.78) | NPC1RAB9AKMT2AMEN1LMNA | |
| SCHEMBL29961413 | 0.60 | LMNA (0.68) | NPC1RAB9AKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478437-B1 | ACC INHIBITORS | PFIZER PROD INC (US) | 2005-08-31 | — | — | EP | claimed |