Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | NT5E | P21589 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6182717 | 0.86 | NPC1 (0.46) | NPC1ALDH1A1RAB9ASMN1; SMN2MAOB | |
| SCHEMBL3459037 | 0.81 | ACACB (0.47) | ALDH1A1SMN1; SMN2LMNAKDM4EHPGD | |
| SCHEMBL6622739 | 0.69 | BCHE (0.33) | — | |
| SCHEMBL975307 | 0.68 | ACACB (0.66) | NPC1ALDH1A1RAB9ALMNAPKM | |
| SCHEMBL28997586 | 0.68 | NPC1 (0.81) | NPC1ALDH1A1RAB9ASMN1; SMN2MAOB | |
| SCHEMBL6620194 | 0.66 | CYP1A2 (0.37) | ALDH1A1KMT2AKDM4EMEN1CYP1A2 | |
| SCHEMBL6624779 | 0.63 | ALDH1A1 (0.40) | NPC1ALDH1A1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL6623086 | 0.63 | RAB9A (0.36) | RAB9ASMN1; SMN2LMNA | |
| SCHEMBL1304331 | 0.62 | GABRP (0.46) | ALDH1A1RAB9APKMKMT2AKDM4E | |
| SCHEMBL7349348 | 0.61 | LMNA (0.78) | NPC1ALDH1A1RAB9ASMN1; SMN2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150265-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE FOR TREATMENT OF NEURONAL HYPOMETABOLISM | Neuera Pharmaceuticals, Inc. (US) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008140828-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE FOR TREATMENT OF NEURONAL HYPOMETABOLISM | ACCERA, INC. (US) | 2008-11-20 | — | — | WO | disclosed |
| EP-1478437-A1 | ACC INHIBITORS | Pfizer Products Inc. (US) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003072197-A1 | ACC INHIBITORS | PFIZER PRODUCTS INC. (US) | 2003-09-04 | — | — | WO | disclosed |