Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25370390 | 0.85 | NUDT1 (0.48) | KDM4EALDH1A1HSD17B10MAPTNUDT1 | |
| SCHEMBL2800784 | 0.81 | TSHR (0.54) | KDM4EALDH1A1HSD17B10KMT2AGAA | |
| SCHEMBL9236279 | 0.78 | TSHR (0.63) | KDM4EALDH1A1HSD17B10MAPTGLA | |
| SCHEMBL25373071 | 0.77 | L3MBTL1 (0.47) | KDM4EALDH1A1HSD17B10KMT2AALOX15 | |
| SCHEMBL10568384 | 0.73 | NLRP3 (0.48) | ALDH1A1ATMTSHRSMN1; SMN2POLB | |
| SCHEMBL7870053 | 0.73 | TSHR (0.56) | KDM4EALDH1A1HSD17B10MAPTGLA | |
| SCHEMBL29151319 | 0.73 | CA12 (0.51) | KDM4EALDH1A1HSD17B10MAPTGLA | |
| SCHEMBL109089 | 0.72 | TSHR (0.54) | KDM4EALDH1A1HSD17B10MAPTGLA | |
| SCHEMBL9476717 | 0.72 | ALDH1A1 (0.51) | KDM4EALDH1A1HSD17B10MAPTGLA | |
| SCHEMBL25372176 | 0.71 | NLRP3 (0.36) | KDM4EALDH1A1HSD17B10MAPTNUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501805-A1 | SUBSTITUTED PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003095430-A1 | SUBSTITUTED PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2003-11-20 | — | — | WO | disclosed |