Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.66 |
| ▸ | MEN1 | O00255 | 6/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.66 |
| ▸ | MAPT | P10636 | 6/20 | 0.66 |
| ▸ | HPGD | P15428 | 6/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.66 |
| ▸ | NPC1 | O15118 | 5/20 | 0.66 |
| ▸ | RAB9A | P51151 | 5/20 | 0.66 |
| ▸ | TP53 | P04637 | 5/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.66 |
| ▸ | ESR1 | P03372 | 3/20 | 0.66 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.66 |
| ▸ | AKR1B10 | O60218 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12678865 | 0.90 | ALDH1A1 (0.68) | EGFRALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL18326518 | 0.89 | EGFR (0.70) | EGFRALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL30525493 | 0.87 | MAPT (0.75) | EGFRALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL13279932 | 0.87 | MAPT (0.75) | EGFRALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL17718213 | 0.83 | EGFR (0.63) | EGFRALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL14341461 | 0.82 | MEN1 (0.56) | EGFRALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL10620481 | 0.82 | SMN1; SMN2 (0.76) | EGFRALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL18326541 | 0.81 | EGFR (0.60) | EGFRALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL16431178 | 0.81 | EGFR (0.67) | EGFRALDH1A1MEN1KMT2AMAPT | |
| Tectorigenin SCHEMBL29353966 | 0.80 | EGFR (1.00) | EGFRALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448542-A4 | 6-HYDROXY ISOFLAVONES, DERIVATIVES AND MEDICAMENTS INVOLVING SAME | NOVOGEN RES PTY LTD (AU) | 2005-11-16 | — | — | EP | disclosed |
| US-20050049424-A1 | 6-Hydroxy isoflavones derivatives and medicaments involving same | NOVOGEN RESEARCH PTY LIMITED (AU) | 2005-03-03 | — | — | US | disclosed |
| EP-1448542-A1 | 6-HYDROXY ISOFLAVONES, DERIVATIVES AND MEDICAMENTS INVOLVING SAME | Novogen Research Pty. Ltd. (AU) | 2004-08-25 | — | — | EP | disclosed |
| WO-2003035635-A1 | 6-HYDROXY ISOFLAVONES, DERIVATIVES AND MEDICAMENTS INVOLVING SAME | NOVOGEN RESEARCH PTY LIMITED (AU) | 2003-05-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050049424-A1 | 6-Hydroxy isoflavones derivatives and medicaments involving same | CYP2A7, CYP3A7, CASP7 | EGFR 824/4885ALDH1A1 2384/4885MEN1 2153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.