SCHEMBL6183517

SCHEMBL6183517

CC(C)c1cccc(C(C)C)c1NC(=O)N(Cc1ccc2oc(=O)[nH]c2c1)C(c1ccccn1)C1CCCCC1

nearest known ligand 0.37

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
NMBR P28336 7/20 0.37
GRPR P30550 1/20 0.37
UBE2M P61081 1/20 0.33
DCUN1D1 Q96GG9 1/20 0.33
SOAT1 P35610 1/20 0.33
USP1 O94782 1/20 0.32
MMP13 P45452 1/20 0.32
KCNH2 Q12809 1/20 0.32
MCHR2 Q969V1 1/20 0.32
MCHR1 Q99705 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6186318 0.83 SOAT1 (0.40) NMBRGRPRUBE2MDCUN1D1SOAT1
SCHEMBL6803558 0.82 UBE2M (0.39) NMBRGRPRUBE2MDCUN1D1
SCHEMBL6185224 0.81 NSD2 (0.39) NMBRGRPRMCHR2MCHR1
SCHEMBL6183039 0.81 UBE2M (0.37) NMBRGRPRUBE2MDCUN1D1
SCHEMBL6805345 0.81 UBE2M (0.43) NMBRGRPRUBE2MDCUN1D1SOAT1
SCHEMBL6185668 0.79 MEN1 (0.37) NMBRGRPRUBE2MDCUN1D1MMP13
SCHEMBL6801844 0.78 UBE2M (0.41) NMBRGRPRUBE2MDCUN1D1
SCHEMBL6183997 0.78 NMBR (0.41) NMBRGRPRUBE2MDCUN1D1SOAT1
SCHEMBL6183511 0.77 NMBR (0.49) NMBR
SCHEMBL6808030 0.76 UBE2M (0.39) NMBRGRPRUBE2MDCUN1D1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1501800-A1 BOMBESIN ANTAGONISTS Warner-Lambert Company LLC (US) 2005-02-02 EP disclosed
US-20040063643-A1 Bombesin antagonists PFIZER INC. 2004-04-01 US disclosed
WO-2003092670-A1 BOMBESIN ANTAGONISTS WARNER-LAMBERT COMPANY LLC (US) 2003-11-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040063643-A1 Bombesin antagonists BRS3, NPSR1, GNRHR NMBR 211/4885GRPR 12/4885UBE2M 3897/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.