Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.35 |
| ▸ | OXTR | P30559 | 2/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1035908 | 0.74 | KDM4E (0.56) | KMT2APOLBALDH1A1MEN1USP2 | |
| SCHEMBL1696116 | 0.71 | KMT2A (0.53) | KMT2APOLBALDH1A1CHRNA7MEN1 | |
| SCHEMBL16476684 | 0.71 | KMT2A (0.53) | KMT2APOLBALDH1A1CHRNA7MEN1 | |
| SCHEMBL6183600 | 0.68 | OXTR (0.37) | KMT2AMEN1TRPM8OXTRAVPR2 | |
| SCHEMBL1036882 | 0.68 | HCRTR1 (0.53) | OXTRAVPR2 | |
| SCHEMBL3550308 | 0.67 | KMT2A (0.52) | KMT2APOLBALDH1A1CHRNA7MEN1 | |
| SCHEMBL1696129 | 0.66 | KMT2A (0.46) | KMT2APOLBALDH1A1CHRNA7MEN1 | |
| SCHEMBL16476747 | 0.66 | KMT2A (0.46) | KMT2APOLBALDH1A1CHRNA7MEN1 | |
| SCHEMBL6069865 | 0.66 | PTGS2 (0.49) | KMT2APOLBALDH1A1CHRNA7MEN1 | |
| SCHEMBL6069855 | 0.66 | PTGS2 (0.49) | KMT2APOLBALDH1A1CHRNA7MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554239-A2 | SULFONYLAMINO-ACETIC ACID DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004033418-A2 | SULFONYLAMINO-ACETIC DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2004-04-22 | — | — | WO | disclosed |