Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.58 |
| ▸ | HTR1A | P08908 | 3/20 | 0.56 |
| ▸ | DRD2 | P14416 | 3/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.56 |
| ▸ | DRD1 | P21728 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | CCKBR | P32239 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6186018 | 0.96 | HTR2A (0.54) | HTR2AHTR1ADRD2ABCB11CHRM2 | |
| SCHEMBL6183391 | 0.90 | HTR2A (0.53) | HTR2AHTR1ADRD2ABCB11CHRM2 | |
| SCHEMBL7235558 | 0.86 | HTR2A (0.49) | HTR2AHTR1ADRD2ABCB11CHRM2 | |
| SCHEMBL6184588 | 0.85 | HTR2A (0.58) | HTR2ADRD2DRD3HTR6 | |
| SCHEMBL6187862 | 0.82 | HTR1D (0.46) | HTR2AKCNH2 | |
| SCHEMBL6182962 | 0.82 | HTR2A (0.55) | HTR2ADRD2DRD3HTR6 | |
| Methyl Alcohol SCHEMBL929693 | 0.80 | CHRM2 (0.65) | HTR2AHTR1ADRD2ABCB11CHRM2 | |
| Methane SCHEMBL7348385 | 0.79 | HTR1A (0.65) | HTR2AHTR1ADRD2ABCB11CHRM2 | |
| SCHEMBL5995122 | 0.79 | HTR1A (0.67) | HTR2AHTR1ADRD2HRH3 | |
| SCHEMBL8795133 | 0.79 | ACHE (0.71) | HTR2AHTR1ADRD2ACHEHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275641-B1 | Benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2005-01-12 | — | — | EP | disclosed |
| US-6541471-B1 | Useful as a TXA2 receptor antagonist and a 5-HT2 receptor antagonist | LES LABORATOIRES SERVIER (FR) | 2003-04-01 | — | — | US | disclosed |
| EP-1275641-A2 | Benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |