Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.51 |
| ▸ | HTR1A | P08908 | 7/20 | 0.51 |
| ▸ | HTR2A | P28223 | 7/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6185306 | 0.96 | HTR1A (0.48) | DRD2HTR1AHTR2AHTR2CADRA1A | |
| SCHEMBL7225838 | 0.89 | DRD2 (0.57) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL7236592 | 0.85 | DRD2 (0.53) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL7225705 | 0.84 | HTR2A (0.56) | DRD2HTR1AHTR2AHTR7HTR6 | |
| Hydrochloric Acid SCHEMBL7226979 | 0.83 | HTR2A (0.55) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL6185944 | 0.81 | ABCB1 (0.51) | DRD2HTR1AHTR2AHTR6 | |
| SCHEMBL6185942 | 0.81 | ABCB1 (0.60) | DRD2HTR1AHTR2AHRH1 | |
| SCHEMBL6182991 | 0.80 | HTR2A (0.53) | DRD2HTR1AHTR2AHTR7HTR6 | |
| Hydrochloric Acid SCHEMBL7225841 | 0.80 | HTR2A (0.52) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL6184672 | 0.78 | ABCB1 (0.53) | DRD2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275641-B1 | Benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2005-01-12 | — | — | EP | disclosed |
| US-6541471-B1 | Useful as a TXA2 receptor antagonist and a 5-HT2 receptor antagonist | LES LABORATOIRES SERVIER (FR) | 2003-04-01 | — | — | US | disclosed |
| EP-1275641-A2 | Benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |