Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | HPGDS | O60760 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9272910 | 0.87 | TSHR (0.64) | AKR1C3TSHRALDH1A1LMNAKMT2A | |
| SCHEMBL4658334 | 0.86 | AKR1C3 (0.61) | AKR1C3TSHRALDH1A1LMNAKMT2A | |
| SCHEMBL1423195 | 0.84 | AKR1C3 (0.66) | AKR1C3TSHRALDH1A1LMNAKMT2A | |
| SCHEMBL16026545 | 0.83 | PKM (0.74) | AKR1C3TSHRALDH1A1LMNAKMT2A | |
| SCHEMBL27829788 | 0.83 | AKR1C3 (0.83) | AKR1C3TSHRALDH1A1LMNAKMT2A | |
| SCHEMBL7793932 | 0.82 | AKR1C3 (0.68) | AKR1C3TSHRALDH1A1LMNAKMT2A | |
| SCHEMBL3904994 | 0.82 | KMT2A (0.68) | AKR1C3TSHRALDH1A1LMNAKMT2A | |
| SCHEMBL6981817 | 0.81 | CYP2C9 (0.45) | AKR1C3TSHRALDH1A1LMNAKMT2A | |
| SCHEMBL8362372 | 0.81 | TSHR (0.68) | AKR1C3TSHRALDH1A1LMNAKMT2A | |
| SCHEMBL30747784 | 0.81 | TSHR (0.68) | AKR1C3TSHRALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083588-B1 | AROMATIC HETEROCYCLIC COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS | SUNSHINE LAKE PHARMA CO LTD (CN) | 2020-12-09 | — | — | EP | disclosed |
| EP-3134392-B1 | SULFONAMIDE DERIVATIVES AND PHARMACEUTICAL APPLICATIONS THEREOF | SUNSHINE LAKE PHARMA CO LTD (CN) | 2019-01-02 | — | — | EP | disclosed |
| US-9840482-B2 | Sulfonamide derivatives and pharmaceutical applications thereof | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2017-12-12 | — | — | US | disclosed |
| US-9663498-B2 | Aromatic heterocyclic compounds and their application in pharmaceuticals | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2017-05-30 | — | — | US | disclosed |
| US-9663498-B2 | Aromatic heterocyclic compounds and their application in pharmaceuticals | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2017-05-30 | — | — | US | disclosed |
| US-20170037017-A1 | Sulfonamide Derivatives And Pharmaceutical Applications Thereof | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2017-02-09 | — | — | US | disclosed |
| US-20160251339-A1 | AROMATIC HETEROCYCLIC COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2016-09-01 | — | — | US | disclosed |
| EP-1049679-B1 | SULPHONAMIDE DERIVATIVES FOR TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 2005-06-01 | — | — | EP | disclosed |
| EP-0994862-B1 | SULPHONAMIDE DERIVATIVES BEING 5-HT6 RECEPTOR ANTAGONISTS AND PROCESS FOR THEIR PREPARATION | SMITHKLINE BEECHAM PLC (GB) | 2005-06-01 | — | — | EP | disclosed |
| US-20040047828-A1 | Ectoin or ection derivatives and surfactants | MERCK PATENT GMBH (DE) | 2004-03-11 | — | — | US | disclosed |
| US-20040034036-A1 | N-(3,5-dichloro-2-methoxyphenyl)-4-methoxy-3-piperazin-1-yl-benzenesulfonamide | SMITHKLINE BEECHMAN P.L.C. (GB) | 2004-02-19 | — | — | US | disclosed |
| WO-2003072198-A1 | THE USE OF A BENZENESULFONAMIDE COMPOUND IN THE TREATMENT OF OBESITY | GLAXO GROUP LIMITED (GB) | 2003-09-04 | — | — | WO | disclosed |
| EP-1313720-A1 | N-(3,5-DICHLORO-2-METHOXYPHENYL)-4-METHOXY-3-PIPERAZIN-1-YL-BENZENESULFONAMIDE | SMITHKLINE BEECHAM PLC (GB) | 2003-05-28 | — | — | EP | disclosed |
| US-6548504-B1 | Compounds | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-04-15 | — | — | US | disclosed |
| WO-2002018358-A1 | N-(3,5-DICHLORO-2-METHOXYPHENYL)-4-METHOXY-3-PIPERAZIN-1-YL-BENZENESULFONAMIDE | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-03-07 | — | — | WO | disclosed |
| US-6316450-B1 | PIPERAZINE COMPOUNDS FOR TREATING DEPRESSION AND ANXIETY | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-11-13 | — | — | US | disclosed |
| EP-1049679-A2 | SULPHONAMIDE DERIVATIVES FOR TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-08 | — | — | EP | disclosed |
| EP-0994862-A2 | SULPHONAMIDE DERIVATIVES BEING 5-HT6 RECEPTOR ANTAGONISTS AND PROCESS FOR THEIR PREPARATION | SMITHKLINE BEECHAM PLC (GB) | 2000-04-26 | — | — | EP | disclosed |
| WO-1999037623-A2 | SULPHONAMIDE DERIVATIVES FOR TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1999-07-29 | — | — | WO | disclosed |
| WO-1999002502-A2 | SULPHONAMIDE DERIVATIVES BEING 5-HT6 RECEPTOR ANTAGONISTS AND PROCESS FOR THEIR PREPARATION | SMITHKLINE BEECHAM PLC (GB) | 1999-01-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160251339-A1 | AROMATIC HETEROCYCLIC COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS | MAPT, APP, PSEN1 | AKR1C3 194/4885TSHR 3458/4885ALDH1A1 1342/4885 |
| US-20170037017-A1 | Sulfonamide Derivatives And Pharmaceutical Applications Thereof | HTR6, SLC6A4, HTR2A | AKR1C3 1080/4885TSHR 610/4885ALDH1A1 1780/4885 |
| US-20040047828-A1 | Ectoin or ection derivatives and surfactants | EFNA1, CERT1, LRAT | AKR1C3 1300/4885TSHR 393/4885ALDH1A1 2485/4885 |
| US-20040034036-A1 | N-(3,5-dichloro-2-methoxyphenyl)-4-methoxy-3-piperazin-1-yl-benzenesulfonamide | PMP22, CNR2, SNCA | AKR1C3 2457/4885TSHR 2110/4885ALDH1A1 964/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.