Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | HPGDS | O60760 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9272910 | 0.87 | TSHR (0.64) | AKR1C3TSHRKMT2AMEN1POLB | |
| SCHEMBL6184895 | 0.86 | AKR1C3 (0.61) | AKR1C3TSHRKMT2AMEN1POLB | |
| SCHEMBL16026545 | 0.83 | PKM (0.74) | AKR1C3TSHRKMT2AMEN1POLB | |
| SCHEMBL27829788 | 0.83 | AKR1C3 (0.83) | AKR1C3TSHRKMT2AMEN1POLB | |
| SCHEMBL7793932 | 0.82 | AKR1C3 (0.68) | AKR1C3TSHRKMT2AMEN1POLB | |
| SCHEMBL3904994 | 0.82 | KMT2A (0.68) | AKR1C3TSHRKMT2AMEN1POLB | |
| SCHEMBL30747784 | 0.81 | TSHR (0.68) | AKR1C3TSHRKMT2AMEN1POLB | |
| SCHEMBL614496 | 0.81 | AKR1C3 (0.58) | AKR1C3TSHRKMT2AMEN1LMNA | |
| SCHEMBL1423195 | 0.81 | AKR1C3 (0.66) | AKR1C3TSHRKMT2AMEN1POLB | |
| SCHEMBL8362372 | 0.81 | TSHR (0.68) | AKR1C3TSHRKMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423106-B1 | ARYLSULFONYL DERIVATIVES WITH 5-HT 6 RECEPTOR AFFINITY | HOFFMANN LA ROCHE (CH) | 2008-12-17 | — | — | EP | disclosed |
| EP-1423106-B1 | ARYLSULFONYL DERIVATIVES WITH 5-HT 6 RECEPTOR AFFINITY | HOFFMANN LA ROCHE (CH) | 2008-12-17 | — | — | EP | disclosed |
| US-6825202-B2 | CENTRAL NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | SYNTEX (U.S.A.) LLC | 2004-11-30 | — | — | US | disclosed |
| EP-1423106-A1 | ARYLSULFONYL DERIVATIVES WITH 5-HT 6 RECEPTOR AFFINITY | F. HOFFMANN-LA ROCHE AG (CH) | 2004-06-02 | — | — | EP | disclosed |
| US-20030069254-A1 | New arylsulfonyl derivatives with 5-HT6 receptor affinity | SYNTEX (U.S.A.) LLC | 2003-04-10 | — | — | US | disclosed |
| WO-2003014097-A1 | ARYLSULFONYL DERIVATIVES WITH 5-HT6 RECEPTOR AFFINITY | F. HOFFMANN-LA ROCHE AG (CH) | 2003-02-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030069254-A1 | New arylsulfonyl derivatives with 5-HT6 receptor affinity | HTR6, HTR1A, HTR4 | AKR1C3 1088/4885TSHR 159/4885KMT2A 1640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.