Dihydrolipoic Acid

Dihydrolipoic Acid

SCHEMBL618576

O=C(O)CCCCC(S)CCS.O=C(O)CCCCC(S)CCS

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
FOLH1 Q04609 5/20 0.56
GSTK1 Q9Y2Q3 2/20 0.55
ENPEP Q07075 4/20 0.53
LMNA P02545 2/20 0.48
ANPEP P15144 1/20 0.47
TSHR P16473 1/20 0.46
NFKB1 P19838 1/20 0.46
PMP22 Q01453 1/20 0.46
FFAR4 Q5NUL3 1/20 0.42
FFAR1 O14842 1/20 0.42
SLC22A6 Q4U2R8 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dihydrolipoic Acid SCHEMBL19773 1.00 FOLH1 (0.56) FOLH1GSTK1ENPEPLMNAANPEP
Dihydrolipoic Acid SCHEMBL1115003 1.00 FOLH1 (0.56) FOLH1GSTK1ENPEPLMNAANPEP
Dihydrolipoic Acid SCHEMBL867951 1.00 FOLH1 (0.56) FOLH1GSTK1ENPEPLMNAANPEP
SCHEMBL6805309 0.98 GSTK1 (0.57) FOLH1GSTK1ENPEPLMNAANPEP
SCHEMBL21611884 0.98 GSTK1 (0.57) FOLH1GSTK1ENPEPLMNAANPEP
Dihydrolipoic Acid SCHEMBL2582098 0.98 FOLH1 (0.54) FOLH1GSTK1ENPEPLMNAANPEP
SCHEMBL6809842 0.98 GSTK1 (0.57) FOLH1GSTK1ENPEPLMNAANPEP
Dihydrolipoic Acid SCHEMBL2578740 0.98 FOLH1 (0.54) FOLH1GSTK1ENPEPLMNAANPEP
Dihydrolipoic Acid SCHEMBL19359055 0.98 FOLH1 (0.54) FOLH1GSTK1ENPEPLMNAANPEP
Dihydrolipoic Acid SCHEMBL4761911 0.96 FOLH1 (0.52) FOLH1GSTK1ENPEPLMNAANPEP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101778576-B Stabilized anthocyanin compositions 欧博康有限公司 2017-07-21 CN disclosed
EP-2442645-A1 CHOLINE ESTERS Encore Health, Llc (US) 2012-04-25 EP disclosed
US-20120039814-A1 Topical Compositions and Methods of Detection and Treatment JOHNS HOPKINS UNIVERSITY 2012-02-16 US disclosed
US-8034833-B2 Phosphorus binder for treatment of renal disease BIOLINK LIFE SCIENCES, INC. (US) 2011-10-11 US disclosed
EP-2364084-A1 LOW DOSE LIPOIC ACID PHARMACEUTICAL COMPOSITIONS AND METHODS Encore Health, Llc (US) 2011-09-14 EP disclosed
US-20110160305-A1 Oral Delivery of Therapeutic Doses of Glutathione AGB INNOVATIONS, LLC 2011-06-30 US disclosed
US-20110098347-A1 PHOSPHOROUS BINDER FOR TREATMENT OF KIDNEY DISEASE BIOLINK LIFE SCIENCES, INC. (US) 2011-04-28 US disclosed
US-7862836-B2 Phosphorus binder for treatment of kidney disease BIOLINK LIFE SCIENCES, INC. (US) 2011-01-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120039814-A1 Topical Compositions and Methods of Detection and Treatment LIPA, TSLP, CUTA FOLH1 559/4885GSTK1 1087/4885ENPEP 1150/4885
US-20110098347-A1 PHOSPHOROUS BINDER FOR TREATMENT OF KIDNEY DISEASE ALPI, PHPT1, FABP2 FOLH1 630/4885GSTK1 3334/4885ENPEP 538/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.