Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 3/20 | 0.51 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.46 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.44 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6185574 | 0.95 | HRH1 (0.52) | HRH1LTB4RLTB4R2KDM4ELMNA | |
| SCHEMBL6184510 | 0.92 | KDM4E (0.50) | HRH1LTB4RLTB4R2KDM4E | |
| SCHEMBL6183446 | 0.89 | HRH1 (0.51) | HRH1KDM4ELMNADRD2DRD1 | |
| SCHEMBL6187276 | 0.83 | HRH1 (0.45) | HRH1LTB4RLTB4R2KDM4E | |
| SCHEMBL7227176 | 0.79 | TBXA2R (0.57) | — | |
| SCHEMBL8702902 | 0.79 | HRH1 (0.73) | HRH1DRD2DRD1DRD4DRD5 | |
| SCHEMBL6185286 | 0.78 | HRH1 (0.46) | HRH1KDM4E | |
| Hydrochloric Acid SCHEMBL8707461 | 0.78 | HRH1 (0.71) | HRH1DRD2DRD1DRD4DRD5 | |
| SCHEMBL6184959 | 0.77 | ALDH1A1 (0.50) | HRH1 | |
| SCHEMBL8703305 | 0.76 | HRH1 (0.73) | HRH1DRD2DRD1DRD4DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275641-B1 | Benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2005-01-12 | — | — | EP | disclosed |
| US-6541471-B1 | Useful as a TXA2 receptor antagonist and a 5-HT2 receptor antagonist | LES LABORATOIRES SERVIER (FR) | 2003-04-01 | — | — | US | disclosed |
| EP-1275641-A2 | Benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |