Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27598250 | 0.80 | LMNA (0.33) | HSD17B10KDM4EHPGDALDH1A1MAPT | |
| SCHEMBL2636627 | 0.78 | KDM4E (0.34) | HSD17B10KDM4EHPGDALDH1A1MAPT | |
| SCHEMBL4632562 | 0.77 | PRKCI (0.38) | HSD17B10KDM4EHPGDALDH1A1MAPT | |
| SCHEMBL7994968 | 0.77 | ATR (0.34) | HSD17B10KDM4EHPGDALDH1A1MAPT | |
| SCHEMBL15940616 | 0.72 | — | — | |
| SCHEMBL6639870 | 0.70 | KDM4E (0.50) | HSD17B10KDM4EHPGDALDH1A1MAPT | |
| SCHEMBL4634043 | 0.69 | TDP1 (0.42) | HSD17B10KDM4EHPGDALDH1A1ALOX15 | |
| SCHEMBL8378283 | 0.69 | KDM4E (0.45) | HSD17B10KDM4EHPGDALDH1A1MAPT | |
| SCHEMBL1198547 | 0.68 | NPSR1 (0.48) | KDM4EALDH1A1MAPTGAA | |
| SCHEMBL8559884 | 0.68 | PTPN11 (0.36) | HSD17B10KDM4EHPGDALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341764-B1 | ORTHO-SUBSTITUTED NITROGEN-CONTAINING BISARYL COMPOUNDS USED AS POTASSIUM CHANNEL INHIBITORS | AVENTIS PHARMA GMBH (DE) | 2005-06-15 | — | — | EP | disclosed |
| EP-1341764-A1 | ORTHO-SUBSTITUTED NITROGEN-CONTAINING BISARYL COMPOUNDS USED AS POTASSIUM CHANNEL INHIBITORS | Aventis Pharma Deutschland GmbH (DE) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002046162-A1 | ORTHO-SUBSTITUTED NITROGEN-CONTAINING BISARYL COMPOUNDS USED AS POTASSIUM CHANNEL INHIBITORS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-06-13 | — | — | WO | disclosed |