Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | HRH2 | P25021 | 7/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6187862 | 0.90 | HTR1D (0.46) | HTR1DHTR1BKCNH2HRH2HTR7 | |
| SCHEMBL7235558 | 0.86 | HTR2A (0.49) | KCNH2 | |
| SCHEMBL6183391 | 0.83 | HTR2A (0.53) | KCNH2 | |
| SCHEMBL7225536 | 0.82 | TBXA2R (0.42) | HTR7 | |
| SCHEMBL7236592 | 0.80 | DRD2 (0.53) | HTR7 | |
| SCHEMBL6185121 | 0.80 | ABCB1 (0.49) | KCNH2ABCB1 | |
| SCHEMBL6182349 | 0.79 | ABCB1 (0.58) | KCNH2ABCB1 | |
| SCHEMBL1545312 | 0.78 | HTR1D (0.50) | HTR1DHTR1BHTR7 | |
| SCHEMBL6185937 | 0.78 | DRD1 (0.51) | KCNH2ABCB1 | |
| Hydrochloric Acid SCHEMBL1545002 | 0.77 | HTR1D (0.49) | HTR1DHTR1BHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275641-B1 | Benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2005-01-12 | — | — | EP | disclosed |
| US-6541471-B1 | Useful as a TXA2 receptor antagonist and a 5-HT2 receptor antagonist | LES LABORATOIRES SERVIER (FR) | 2003-04-01 | — | — | US | disclosed |
| EP-1275641-A2 | Benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |