Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 5/20 | 0.81 |
| ▸ | DRD2 | P14416 | 3/20 | 0.81 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.74 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.74 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.74 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8712702 | 0.90 | DRD2 (1.00) | DRD4DRD2 | |
| SCHEMBL61848 | 0.89 | TMEM97 (0.83) | DRD4DRD2TMEM97SIGMAR1SLC6A12 | |
| SCHEMBL694949 | 0.88 | SIGMAR1 (0.82) | DRD4DRD2TMEM97SIGMAR1SLC6A12 | |
| SCHEMBL7218186 | 0.86 | DRD4 (0.86) | DRD4DRD2TMEM97SIGMAR1SLC6A12 | |
| SCHEMBL2233466 | 0.86 | KCNH2 (0.80) | DRD4DRD2TMEM97SIGMAR1SLC6A12 | |
| SCHEMBL7224869 | 0.85 | SIGMAR1 (0.77) | DRD4DRD2TMEM97SIGMAR1SLC6A12 | |
| SCHEMBL8274001 | 0.85 | MEN1 (0.78) | DRD4DRD2TMEM97SIGMAR1SLC6A12 | |
| SCHEMBL1425074 | 0.85 | SIGMAR1 (1.00) | DRD4DRD2TMEM97SIGMAR1SLC6A12 | |
| SCHEMBL2233461 | 0.85 | TMEM97 (0.77) | DRD4DRD2TMEM97SIGMAR1SLC6A12 | |
| SCHEMBL3366478 | 0.85 | SIGMAR1 (1.00) | DRD4DRD2TMEM97SIGMAR1SLC6A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231666-B1 | Carboxamide, sulfonamide and amine compounds for metabolic disorders | RIGEL PHARMACEUTICALS INC (US) | 2015-07-29 | — | — | EP | disclosed |
| US-8895578-B2 | Carboxamide, sulfonamide and amine compounds and methods for using the same | RIGEL PHARMACEUTICALS, INC. (US) | 2014-11-25 | — | — | US | disclosed |
| US-20140045882-A1 | Carboxamide, Sulfonamide and Amine Compounds and Methods for Using The Same | RIGEL PHARMACEUTICALS, INC. (US) | 2014-02-13 | — | — | US | disclosed |
| US-8557822-B2 | Carboxamide, sulfonamide and amine compounds and methods for using the same | RIGEL PHARMACEUTICALS, INC. (US) | 2013-10-15 | — | — | US | disclosed |
| US-20120108606-A1 | Carboxamide, Sulfonamide and Amine Compounds and Methods for Using The Same | RIGEL PHARMACEUTICALS, INC. (US) | 2012-05-03 | — | — | US | disclosed |
| US-8129390-B2 | Carboxamide, sulfonamide and amine compounds and methods for using the same | RIGEL PHARMACEUTICALS, INC. (US) | 2012-03-06 | — | — | US | disclosed |
| US-20090163511-A1 | Carboxamide, Sulfonamide and Amine Compounds and Methods for Using The Same | RIGEL PHARMACEUTICALS, INC. (US) | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108606-A1 | Carboxamide, Sulfonamide and Amine Compounds and Methods for Using The Same | AK2, PRKAA1, PRKAA2 | DRD4 2946/4885DRD2 2100/4885TMEM97 2354/4885 |
| US-20090163511-A1 | Carboxamide, Sulfonamide and Amine Compounds and Methods for Using The Same | AK2, PRKAA1, PRKAA2 | DRD4 2946/4885DRD2 2100/4885TMEM97 2354/4885 |
| US-20140045882-A1 | Carboxamide, Sulfonamide and Amine Compounds and Methods for Using The Same | AK2, PRKAA1, PRKAA2 | DRD4 2946/4885DRD2 2100/4885TMEM97 2354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.