Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8812832 | 0.86 | SIGMAR1 (0.38) | CHRM5CHRM3SIGMAR1TSHRHTR2C | |
| SCHEMBL6299872 | 0.85 | CHRM5 (0.37) | CHRM5CHRM3SIGMAR1TSHRHTR2C | |
| SCHEMBL8024517 | 0.81 | SIGMAR1 (0.38) | CHRM5CHRM3SIGMAR1POLB | |
| SCHEMBL8813389 | 0.79 | TSHR (0.40) | POLBPKMTSHRKDM4E | |
| SCHEMBL8968613 | 0.78 | ITGB3 (0.34) | CHRM5CHRM3SIGMAR1TSHRKMT2A | |
| SCHEMBL1083303 | 0.77 | TSHR (0.42) | POLBPKMTSHRKDM4E | |
| SCHEMBL9559920 | 0.76 | HTR2C (0.34) | CHRM5CHRM3SIGMAR1ATMHTR2C | |
| SCHEMBL2383924 | 0.76 | KDM4E (0.37) | CHRM5CHRM3SIGMAR1TSHRKDM4E | |
| SCHEMBL27681986 | 0.76 | HTR6 (0.39) | ATMHTR2CHTR6 | |
| SCHEMBL27682097 | 0.74 | HTR6 (0.40) | ATMHTR2CHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-A4 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2005-03-30 | — | — | EP | disclosed |
| EP-1465631-A2 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI Pharmaceuticals, Inc. (US) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003053366-A2 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARMACEUTICALS, INC. (US) | 2003-07-03 | — | — | WO | disclosed |