Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | PADI1 | Q9ULC6 | 1/20 | 0.36 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8812832 | 0.82 | SIGMAR1 (0.38) | SIGMAR1CHRM5CHRM3SMN1; SMN2 | |
| SCHEMBL6187054 | 0.81 | CHRM5 (0.37) | SIGMAR1CHRM5CHRM3POLB | |
| SCHEMBL6299872 | 0.81 | CHRM5 (0.37) | SIGMAR1CHRM5CHRM3SMN1; SMN2 | |
| SCHEMBL5386436 | 0.80 | OPRK1 (0.39) | SIGMAR1CHRM5CHRM3OPRK1EPHX2 | |
| SCHEMBL30335980 | 0.76 | CHRM5 (0.33) | SIGMAR1CHRM5CHRM3SMN1; SMN2CHRNB2 | |
| SCHEMBL21649396 | 0.76 | CHRM5 (0.33) | SIGMAR1CHRM5CHRM3SMN1; SMN2CHRNB2 | |
| SCHEMBL27681986 | 0.76 | HTR6 (0.39) | — | |
| SCHEMBL13737943 | 0.75 | CHRNB2 (0.39) | SIGMAR1CHRM5CHRM3PADI1PADI4 | |
| SCHEMBL29170253 | 0.74 | GRM2 (0.35) | SIGMAR1 | |
| SCHEMBL29170258 | 0.74 | GRM2 (0.35) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1067067-C | Heterocyclic tachykinin receptor antagonists | LILLY CO ELI (US) | 2001-06-13 | — | — | CN | disclosed |
| EP-0912178-A4 | METHODS OF TREATING HYPERTENSION | LILLY CO ELI (US) | 2000-08-16 | — | — | EP | disclosed |
| US-6017930-A | Methods of treating or preventing interstitial cystitis | ELI LILLY AND COMPANY (US) | 2000-01-25 | — | — | US | disclosed |
| US-6001837-A | Methods of treating or preventing sleep apnea | ELI LILLY AND COMPANY (US) | 1999-12-14 | — | — | US | disclosed |
| EP-0912178-A1 | METHODS OF TREATING HYPERTENSION | ELI LILLY AND COMPANY (US) | 1999-05-06 | — | — | EP | disclosed |
| EP-0710479-B1 | Use of a serotonin agonist in combination with a tachykinin receptor antagonist for the manufacture of a medicament for the treatment or prevention of migraine | LILLY CO ELI (US) | 1999-01-07 | — | — | EP | disclosed |
| US-5846973-A | Methods of treating pulmonary hypertension | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| US-5744482-A | Serotonin agonist in combination with a tachykinin receptor antagonist in the treatment or prevention of migraine | ELI LILLY AND COMPANY (US) | 1998-04-28 | — | — | US | disclosed |
| WO-1997044035-A1 | METHODS OF TREATING HYPERTENSION | ELI LILLY AND COMPANY (US) | 1997-11-27 | — | — | WO | disclosed |
| WO-1997031633-A1 | METHODS OF TREATING OR PREVENTING SLEEP APNEA | ELI LILLY AND COMPANY (US) | 1997-09-04 | — | — | WO | disclosed |
| WO-1996041633-A1 | METHODS OF TREATING COLD AND ALLERGIC RHINITIS | ELI LILLY AND COMPANY (US) | 1996-12-27 | — | — | WO | disclosed |
| EP-0747049-A1 | Use of tachykinin antagonists in combination with serotonin agonists or serotonin reuptake inhibitors for the manufacture of a medicament for the treatment of allergic rhinitis | ELI LILLY AND COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |
| EP-0747055-A2 | Use of tachykinin receptors antagonists for the treatment of cold and allergic rhinitis | ELI LILLY AND COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |
| WO-1996029074-A1 | METHODS OF TREATING OR PREVENTING PAIN OR NOCICEPTION | ELI LILLY AND COMPANY (US) | 1996-09-26 | — | — | WO | disclosed |
| WO-1996024353-A1 | METHODS OF TREATING OR PREVENTING PSYCHIATRIC DISORDERS | ELI LILLY AND COMPANY (US) | 1996-08-15 | — | — | WO | disclosed |
| US-5530009-A | TREATING ASTHMA | ELI LILLY AND COMPANY (US) | 1996-06-25 | — | — | US | disclosed |
| EP-0710479-A1 | Use of a serotonin agonist in combination with a tachykinin receptor antagonist for the manufacture of a medicament for the treatment or prevention of migraine | ELI LILLY AND COMPANY (US) | 1996-05-08 | — | — | EP | disclosed |
| WO-1996011000-A1 | METHODS OF TREATING MIGRAINE | ELI LILLY AND COMPANY (US) | 1996-04-18 | — | — | WO | disclosed |
| WO-1996001819-A1 | HETEROCYCLIC TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-01-25 | — | — | WO | disclosed |
| EP-0693489-A1 | Heterocyclic tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 1996-01-24 | — | — | EP | disclosed |