SCHEMBL6187669

SCHEMBL6187669

CSC(NCc1ccccc1)=C(C#N)C#N

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.53
MCL1 Q07820 1/20 0.46
HPGD P15428 3/20 0.44
CA12 O43570 2/20 0.44
CA1 P00915 2/20 0.44
CA2 P00918 2/20 0.44
CA9 Q16790 2/20 0.44
MAPT P10636 3/20 0.43
LMNA P02545 2/20 0.43
PLIN1 O60240 1/20 0.43
PLIN5 Q00G26 1/20 0.43
ABHD5 Q8WTS1 1/20 0.43
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
ALOX12 P18054 2/20 0.43
ALDH1A1 P00352 2/20 0.43
KMT2A Q03164 3/20 0.42
GAA P10253 2/20 0.42
MEN1 O00255 2/20 0.42
POLB P06746 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8124285 0.84 EPHX2 (0.42) IDO1MAPTLMNANPC1ALDH1A1
SCHEMBL8129222 0.81 ALDH1A1 (0.51) HPGDMAPTLMNANPC1RAB9A
SCHEMBL8115432 0.80 ALDH1A1 (0.51) HPGDLMNAALDH1A1KMT2AMEN1
SCHEMBL22307220 0.80 LMNA (0.46) HPGDCA2MAPTLMNANPC1
SCHEMBL22306421 0.77 HPGD (0.51) IDO1MCL1HPGDCA12CA1
SCHEMBL8579767 0.76 NAMPT (0.46) CA1CA2MAPTGAATDP1
SCHEMBL3663000 0.75 ALDH1A1 (0.55) MAPTLMNANPC1RAB9AALDH1A1
SCHEMBL8575481 0.75 GLS (0.48) IDO1
SCHEMBL7491252 0.75 HPGD (0.47) IDO1MCL1HPGDMAPTLMNA
SCHEMBL7491255 0.75 HPGD (0.47) IDO1MCL1HPGDMAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020156298-A1 APPLICATION OF MALONONITRILE COMPOUND AS BACTERICIDE 沈阳化工大学 2020-08-06 WO disclosed
EP-0929553-B1 PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF NOVARTIS AG (CH) 2005-03-16 EP disclosed
EP-0760362-B1 DIAMINOMETHYLIDENE DERIVATIVE NISSHIN SEIFUN GROUP INC (JP) 2002-08-14 EP disclosed
US-6251911-B1 Pyrimidine derivatives and processes for the preparation thereof NOVARTIS AG (CH) 2001-06-26 US disclosed
EP-0819129-B1 PYRAZOLE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF NOVARTIS AG (CH) 2000-08-02 EP disclosed
US-5981533-A INHIBIT THE TYROSINE KINASE ACTIVITY OF THE RECEPTOR FOR EPIDERMAL GROWTH FACTOR AND CAN BE USED IN THE CASE OF EPIDERMAL HYPERPROLIFERATION (PSORIASIS) AND AS ANTI-TUMOR AGENTS NOVARTIS AG (CH) 1999-11-09 US disclosed
EP-0929553-A1 PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF Novartis AG (CH) 1999-07-21 EP disclosed
US-5753654-A GASTROINTESTINAL DISORDERS NISSHIN FLOUR MILLING CO., LTD. (JP) 1998-05-19 US disclosed
WO-1998014451-A1 FUSED PYRAZOLE DERIVATIVE AND PROCESS FOR ITS PREPARATION NOVARTIS AG (CH) 1998-04-09 WO disclosed
WO-1998014449-A1 FUSED PYRAZOLE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION NOVARTIS AG (CH) 1998-04-09 WO disclosed
WO-1998014450-A1 PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF NOVARTIS AG (CH) 1998-04-09 WO disclosed
EP-0819129-A1 PYRAZOLE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF Novartis AG (CH) 1998-01-21 EP disclosed
EP-0760362-A1 NOVEL DIAMINOMETHYLIDENE DERIVATIVE NISSHIN FLOUR MILLING CO., LTD. (JP) 1997-03-05 EP disclosed
WO-1996031510-A1 PYRAZOLE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF NOVARTIS AG (CH) 1996-10-10 WO disclosed