Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 9/20 | 0.61 |
| ▸ | HTR7 | P34969 | 6/20 | 0.52 |
| ▸ | HTR1A | P08908 | 4/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | DRD3 | P35462 | 3/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | DRD5 | P21918 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 4/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6184857 | 0.96 | ABCB1 (0.61) | ABCB1HTR7HTR1AHTR2AHTR2C | |
| SCHEMBL6184263 | 0.91 | ABCB1 (0.51) | ABCB1HTR7HTR1AHTR2AHTR2C | |
| SCHEMBL6182420 | 0.87 | ABCB1 (0.50) | ABCB1HTR7 | |
| SCHEMBL6184568 | 0.77 | TBXA2R (0.54) | — | |
| SCHEMBL4176822 | 0.76 | ABCB1 (1.00) | ABCB1DRD2 | |
| SCHEMBL7225705 | 0.76 | HTR2A (0.56) | HTR7HTR1AHTR2ADRD2HTR6 | |
| SCHEMBL6183970 | 0.75 | TBXA2R (0.56) | — | |
| Hydrochloric Acid SCHEMBL7226979 | 0.75 | HTR2A (0.55) | HTR7HTR1AHTR2ADRD2HTR6 | |
| SCHEMBL6183084 | 0.75 | TBXA2R (0.54) | — | |
| SCHEMBL4182261 | 0.74 | ABCB1 (1.00) | ABCB1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275641-B1 | Benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2005-01-12 | — | — | EP | disclosed |
| EP-1275641-A2 | Benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |