Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21342392 | 0.86 | HPGD (0.75) | HPGDKMT2AMEN1KDM4EL3MBTL1 | |
| SCHEMBL10982724 | 0.86 | HPGD (0.75) | HPGDKMT2AMEN1HDAC8HDAC6 | |
| SCHEMBL31117181 | 0.84 | POLB (0.60) | HPGDKMT2AMEN1HDAC8HDAC6 | |
| SCHEMBL10986259 | 0.83 | MEN1 (0.59) | HPGDKMT2AMEN1HDAC8HDAC6 | |
| SCHEMBL19649663 | 0.80 | MEN1 (0.47) | HPGDKMT2AMEN1HDAC8HDAC6 | |
| SCHEMBL11196739 | 0.80 | MEN1 (0.55) | HPGDKMT2AMEN1HDAC8HDAC6 | |
| SCHEMBL9828810 | 0.80 | SHMT1 (0.61) | HPGDKMT2AMEN1HDAC8HDAC6 | |
| SCHEMBL15651888 | 0.79 | NAT1 (0.43) | HPGDKMT2AKDM4EL3MBTL1LMNA | |
| SCHEMBL25144167 | 0.79 | HPGD (0.56) | HPGDKMT2AMEN1HDAC8HDAC6 | |
| SCHEMBL9360320 | 0.79 | P2RX7 (0.55) | HPGDKMT2AMEN1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804437-B1 | [a]-ANNELATED PYRROLE DERIVATIVES AND PHARMACEUTICAL USES THEREOF | MERCKLE GMBH (DE) | 2005-09-14 | — | — | EP | disclosed |
| US-5939415-A | A!-annellated pyrrole derivatives and their use in pharmacology | MERCKLE GMBH (DE) | 1999-08-17 | — | — | US | disclosed |
| EP-0804437-A1 | [a]-ANNELATED PYRROLE DERIVATIVES AND PHARMACEUTICAL USES THEREOF | MERCKLE GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| WO-1995032971-A1 | [a]-ANNELATED PYRROLE DERIVATIVES AND PHARMACEUTICAL USES THEREOF | MERCKLE GMBH (DE) | 1995-12-07 | — | — | WO | disclosed |