SCHEMBL618912

SCHEMBL618912

c1ccc(P(c2ccccc2)c2ccoc2)cc1

nearest known ligand 0.57

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.57
TDP1 Q9NUW8 1/20 0.57
ESR1 P03372 2/20 0.44
ESR2 Q92731 2/20 0.44
KDM4E B2RXH2 1/20 0.35
GAA P10253 1/20 0.35
MAPT P10636 1/20 0.35
MMP2 P08253 1/20 0.33
NPSR1 Q6W5P4 1/20 0.32
GPR52 Q9Y2T5 1/20 0.32
DRD1 P21728 1/20 0.32
IMPDH2 P12268 1/20 0.31
ADORA2A P29274 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL618776 0.87 MMP2 (0.40) CYP3A4TDP1MMP2
Iodide SCHEMBL7778537 0.76 TDP1 (0.86) CYP3A4TDP1ESR1ESR2KDM4E
Iodide SCHEMBL7641328 0.76 TDP1 (0.86) CYP3A4TDP1ESR1ESR2KDM4E
Iodide SCHEMBL10601355 0.76 TDP1 (0.86) CYP3A4TDP1ESR1ESR2KDM4E
Iodide SCHEMBL11676491 0.76 TDP1 (0.86) CYP3A4TDP1ESR1ESR2KDM4E
Iodide SCHEMBL15193635 0.76 TDP1 (0.86) CYP3A4TDP1ESR1ESR2KDM4E
Iodide SCHEMBL11614732 0.76 TDP1 (0.86) CYP3A4TDP1ESR1ESR2KDM4E
Iodide SCHEMBL11614727 0.76 TDP1 (0.86) CYP3A4TDP1ESR1ESR2KDM4E
Iodide SCHEMBL809369 0.76 TDP1 (0.86) CYP3A4TDP1ESR1ESR2KDM4E
Iodide SCHEMBL4444588 0.76 TDP1 (0.86) CYP3A4TDP1ESR1ESR2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130001472-A1 THIN FILM AND COMPOUND USED IN THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-01-03 US disclosed
CN-102822185-A Thin film and compound used in the same SUMITOMO CHEMICAL CO 2012-12-12 CN disclosed
CN-102414178-A Metal complex having aromatic ligand that contains nitrogen atom SUMITOMO CHEMICAL CO 2012-04-11 CN disclosed
EP-2423192-A1 METAL COMPLEX HAVING AROMATIC LIGAND THAT CONTAINS NITROGEN ATOM Sumitomo Chemical Company, Limited (JP) 2012-02-29 EP disclosed
US-20120041203-A1 METAL COMPLEX HAVING AROMATIC RING LIGAND CONTAINING NITROGEN ATOM SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-02-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120041203-A1 METAL COMPLEX HAVING AROMATIC RING LIGAND CONTAINING NITROGEN ATOM MICA, CD4, CLTC CYP3A4 4299/4885TDP1 4839/4885ESR1 1525/4885
US-20130001472-A1 THIN FILM AND COMPOUND USED IN THE SAME NR2E3, NR3C1, NR0B2 CYP3A4 1842/4885TDP1 4067/4885ESR1 45/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.