Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 3/20 | 0.49 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.49 |
| ▸ | CACNB1 | Q02641 | 3/20 | 0.49 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 2/20 | 0.47 |
| ▸ | MMP9 | P14780 | 2/20 | 0.47 |
| ▸ | MMP13 | P45452 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MMP7 | P09237 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1383367 | 0.81 | GAA (0.58) | LMNAMAPTALDH1A1HTTUSP2 | |
| SCHEMBL4041221 | 0.80 | ALDH1A1 (0.49) | LMNAMAPTNPSR1MMP1MMP9 | |
| SCHEMBL7346677 | 0.79 | MMP1 (0.54) | MMP1MMP9MMP13ALDH1A1MMP3 | |
| SCHEMBL1380921 | 0.76 | MMP1 (0.54) | LMNAMAPTMMP1MMP9MMP13 | |
| SCHEMBL6190434 | 0.75 | GAA (0.48) | LMNANPSR1ALDH1A1HTTUSP2 | |
| SCHEMBL17512449 | 0.74 | CACNA2D1 (0.81) | CACNA2D1CACNA1BCACNB1CACNA1CLMNA | |
| SCHEMBL5234080 | 0.74 | ALDH1A1 (0.53) | MMP1MMP9MMP13ALDH1A1HTT | |
| SCHEMBL1382978 | 0.73 | SMN1; SMN2 (0.53) | LMNAMMP1MMP9MMP13ALDH1A1 | |
| SCHEMBL1380848 | 0.72 | CACNA2D1 (0.51) | CACNA2D1CACNA1BCACNB1CACNA1CLMNA | |
| SCHEMBL695071 | 0.72 | MMP2 (0.59) | LMNAMAPTNPSR1MMP9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592389-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | Applied Research Systems ARS Holding N.V. (AN) | 2005-11-09 | — | — | EP | disclosed |
| WO-2004071390-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-08-26 | — | — | WO | disclosed |