Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 4/20 | 0.79 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.79 |
| ▸ | RAB9A | P51151 | 6/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.70 |
| ▸ | MEN1 | O00255 | 4/20 | 0.70 |
| ▸ | NPC1 | O15118 | 3/20 | 0.70 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.69 |
| ▸ | HTT | P42858 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | RECQL | P46063 | 1/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
| ▸ | BLM | P54132 | 1/20 | 0.68 |
| ▸ | EGFR | P00533 | 1/20 | 0.67 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10090723 | 0.92 | PARP1 (0.76) | KCNK3KCNK9RAB9AKMT2AMEN1 | |
| SCHEMBL11474210 | 0.91 | RAB9A (0.69) | KCNK3KCNK9RAB9AKMT2AMEN1 | |
| SCHEMBL2298254 | 0.88 | KCNK3 (1.00) | KCNK3KCNK9RAB9AKMT2AMEN1 | |
| SCHEMBL26845896 | 0.88 | PARP1 (0.66) | KCNK3KCNK9RAB9AKMT2AMEN1 | |
| SCHEMBL13601060 | 0.87 | HDAC1 (0.77) | KCNK3KCNK9RAB9AKMT2AMEN1 | |
| SCHEMBL679144 | 0.87 | KMT2A (0.90) | KCNK3KCNK9RAB9AKMT2AMEN1 | |
| SCHEMBL12096453 | 0.87 | L3MBTL1 (0.68) | KCNK3KCNK9RAB9AKMT2AMEN1 | |
| SCHEMBL8910428 | 0.86 | NPC1 (0.92) | KCNK3KCNK9RAB9AKMT2AMEN1 | |
| SCHEMBL7500312 | 0.85 | KMT2A (0.84) | KCNK3KCNK9RAB9AKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL2106175 | 0.85 | KMT2A (0.87) | KCNK3KCNK9RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1129075-A1 | N-ARYL(THIO)ANTHRANILIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS VEGF RECEPTOR TYROSINE KINASE INHIBITORS | Novartis AG (CH) | 2001-09-05 | — | — | EP | claimed |
| WO-2000027820-A1 | N-ARYL(THIO)ANTHRANILIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS VEGF RECEPTOR TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2000-05-18 | — | — | WO | claimed |
| EP-1129075-A1 | N-ARYL(THIO)ANTHRANILIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS VEGF RECEPTOR TYROSINE KINASE INHIBITORS | Novartis AG (CH) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000027820-A1 | N-ARYL(THIO)ANTHRANILIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS VEGF RECEPTOR TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2000-05-18 | — | — | WO | disclosed |