Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | BAD | Q92934 | 1/20 | 0.33 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.32 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6155424 | 0.88 | CYP4F2 (0.36) | CTSBALOX15ALOX12SLC5A1SLC5A2 | |
| SCHEMBL13018533 | 0.83 | CTSB (0.42) | CTSB | |
| SCHEMBL23612453 | 0.83 | PARP1 (0.42) | ALOX15ALOX12SLC5A1SLC5A2 | |
| SCHEMBL6157517 | 0.81 | HIF1A (0.35) | ALOX15ALOX12 | |
| SCHEMBL5534700 | 0.79 | HIF1A (0.32) | MAPTCTSBALOX15ALOX12 | |
| Acetic Acid SCHEMBL5482093 | 0.78 | KDM4E (0.38) | KDM4EALDH1A1GAAMAPTCTSB | |
| SCHEMBL367973 | 0.77 | ALOX15 (0.53) | PTGS2KDM4EALDH1A1ALOX5GAA | |
| SCHEMBL31490194 | 0.77 | ALOX15 (0.53) | PTGS2KDM4EALDH1A1ALOX5GAA | |
| SCHEMBL19143726 | 0.76 | ALOX15 (0.39) | ALOX15ALOX12 | |
| SCHEMBL7274506 | 0.76 | MTNR1A (0.40) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554264-A2 | MEDICINAL ARYLETHANOLAMINE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004037807-A9 | MEDICINAL ARYLETHANOLAMINE COMPOUNDS | GLAXO GROUP LTD (GB) | 2004-08-19 | — | — | WO | disclosed |
| WO-2004037807-A2 | MEDICINAL ARYLETHANOLAMINE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2004-05-06 | — | — | WO | disclosed |