Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | GNAI3 | P08754 | 3/20 | 0.46 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.46 |
| ▸ | GNAI1 | P63096 | 3/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16509315 | 0.89 | SLC6A1 (0.47) | ALOX15TSHREPHX1EPHX2GNAI3 | |
| SCHEMBL10272310 | 0.89 | SLC6A1 (0.47) | ALOX15TSHREPHX1EPHX2GNAI3 | |
| SCHEMBL256679 | 0.86 | — | — | |
| SCHEMBL6189244 | 0.85 | ALOX15 (0.53) | ALOX15TSHREPHX1EPHX2GNAI3 | |
| SCHEMBL8269740 | 0.82 | FAAH (0.55) | ALOX15TSHREPHX1EPHX2GNAI3 | |
| SCHEMBL1608481 | 0.82 | MEN1 (0.43) | ALOX15TDP1MTNR1AMEN1KMT2A | |
| SCHEMBL21941874 | 0.82 | EPHX1 (0.48) | EPHX1TDP1MTNR1AMEN1KMT2A | |
| SCHEMBL9967995 | 0.82 | EPHX1 (0.53) | EPHX1TDP1MEN1KMT2AFAAH | |
| SCHEMBL11690 | 0.81 | MEN1 (0.45) | ALOX15TSHREPHX1GNAI3GNAO1 | |
| SCHEMBL8269753 | 0.81 | GNAI3 (0.59) | ALOX15TSHREPHX1EPHX2GNAI3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572669-A2 | 2,5-DIKETOPIPERAZINES FOR THE TREATMENT OF OBESITY | NOVO NORDISK A/S (DK) | 2005-09-14 | — | — | EP | claimed |
| WO-2004048345-A2 | 2,5-DIKETOPIPERAZINES FOR THE TREATMENT OF OBESITY | NOVO NORDISK A/S (DK) | 2004-06-10 | — | — | WO | claimed |
| US-5189045-A | Antiserotonine agent | ADIR ET COMPAGNIE (FR) | 1993-02-23 | — | — | US | disclosed |