Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 13/20 | 0.69 |
| ▸ | FAAH | O00519 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CCR3 | P51677 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4486515 | 0.90 | ALDH1A1 (0.62) | SIGMAR1ALDH1A1 | |
| SCHEMBL4485401 | 0.86 | SLC6A3 (0.62) | SIGMAR1ALDH1A1 | |
| SCHEMBL6550825 | 0.83 | SIGMAR1 (1.00) | SIGMAR1CCR3 | |
| SCHEMBL2962629 | 0.83 | SIGMAR1 (1.00) | SIGMAR1CCR3 | |
| SCHEMBL27597094 | 0.82 | SIGMAR1 (0.70) | SIGMAR1FAAHALDH1A1 | |
| SCHEMBL21418234 | 0.81 | ALDH1A1 (0.60) | SIGMAR1ALDH1A1CCR3 | |
| SCHEMBL27564901 | 0.81 | SIGMAR1 (0.73) | SIGMAR1FAAHALDH1A1 | |
| SCHEMBL3158860 | 0.80 | ALDH1A1 (0.68) | SIGMAR1ALDH1A1 | |
| SCHEMBL22266181 | 0.79 | KDM4E (0.67) | SIGMAR1ALDH1A1 | |
| SCHEMBL5365328 | 0.79 | ALDH1A1 (0.64) | SIGMAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-A4 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2005-03-30 | — | — | EP | disclosed |
| EP-1465631-A2 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI Pharmaceuticals, Inc. (US) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003053366-A2 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARMACEUTICALS, INC. (US) | 2003-07-03 | — | — | WO | disclosed |