Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 3/20 | 0.48 |
| ▸ | CES1 | P23141 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22790321 | 0.84 | ACHE (0.46) | CES2CES1TDP1KMT2ALMNA | |
| SCHEMBL1990301 | 0.76 | CES2 (0.55) | CES2CES1TDP1KMT2ALMNA | |
| SCHEMBL20822051 | 0.73 | CES2 (0.34) | CES2CES1TDP1KMT2AMEN1 | |
| SCHEMBL167447 | 0.72 | CES2 (0.64) | CES2CES1TDP1KMT2ALMNA | |
| SCHEMBL14333527 | 0.72 | CES2 (0.50) | CES2CES1KMT2ALMNAMEN1 | |
| SCHEMBL7924194 | 0.72 | CES2 (0.50) | CES2CES1TDP1KMT2ALMNA | |
| SCHEMBL12332545 | 0.72 | CES2 (0.34) | CES2CES1KMT2AERN1GAA | |
| SCHEMBL10040477 | 0.71 | CES2 (0.56) | CES2CES1KMT2AERN1ACHE | |
| SCHEMBL8597809 | 0.71 | CES2 (0.44) | CES2CES1TDP1KMT2AMEN1 | |
| SCHEMBL16223170 | 0.71 | CES2 (0.44) | CES2CES1TDP1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1124827-B1 | 3-(SUBSTITUTED PHENYL)-5-(SUBSTITUTED HETEROCYCLYL)-1,2,4-TRIAZOLE COMPOUNDS | DOW AGROSCIENCES LLC (US) | 2005-11-30 | — | — | EP | disclosed |
| EP-1123281-B1 | 3-(SUBSTITUTED PHENYL)-5-(SUBSTITUTED CYCLOPROPYL)-1,2,4-TRIAZOLE COMPOUNDS | DOW AGROSCIENCES LLC (US) | 2003-10-22 | — | — | EP | disclosed |
| US-6417187-B2 | PALLADIUM CATALYZED ARYLATION, ALKYLATION, DEIODINATION OR DEBROMINATION | DOW AGROSCIENCES LLC | 2002-07-09 | — | — | US | disclosed |
| US-6413997-B1 | INSECTICIDES, MITICIDES | DOW AGROSCIENCES LLC | 2002-07-02 | — | — | US | disclosed |
| US-20020019370-A1 | Palladium catalyzed arylation, alkylation, deiodination or debromination | DOW AGROSCIENCES LLC | 2002-02-14 | — | — | US | disclosed |
| EP-0922043-B1 | PESTICIDAL 3-(SUBSTITUTED PHENYL)-5-(THIENYL OR FURYL)-1,2,4-TRIAZOLES | DOW AGROSCIENCES LLC (US) | 2002-01-30 | — | — | EP | disclosed |
| EP-1124827-A1 | 3-(SUBSTITUTED PHENYL)-5-(SUBSTITUTED HETEROCYCLYL)-1,2,4-TRIAZOLE COMPOUNDS | Dow AgroSciences LLC (US) | 2001-08-22 | — | — | EP | disclosed |
| EP-1123281-A1 | 3-(SUBSTITUTED PHENYL)-5-(SUBSTITUTED CYCLOPROPYL)-1,2,4-TRIAZOLE COMPOUNDS | Dow AgroSciences LLC (US) | 2001-08-16 | — | — | EP | disclosed |
| US-6262305-B1 | Process and intermediates for preparing 3-(substituted phenyl)-5-(thienyl or furyl)-1,2,4-triazole compounds | DOW AGROSCIENCES LLC | 2001-07-17 | — | — | US | disclosed |
| US-6262099-B1 | USEFUL AS INSECTICIDES AND ACARICIDES. | DOW AGROSCIENCES LLC | 2001-07-17 | — | — | US | disclosed |
| EP-1113004-A2 | Intermediates for producing 3-(substituted phenyl)-5-(thienyl or furyl)-1,2,4-triazole compounds | Dow Agrosciences LLC (US) | 2001-07-04 | — | — | EP | disclosed |
| WO-2000024739-A1 | 3-(SUBSTITUTED PHENYL)-5-(SUBSTITUTED HETEROCYCLYL)-1,2,4-TRIAZOLE COMPOUNDS | DOW AGROSCIENCES LLC (US) | 2000-05-04 | — | — | WO | disclosed |
| WO-2000024720-A1 | 3-(SUBSTITUTED PHENYL)-5-(SUBSTITUTED CYCLOPROPYL)-1,2,4-TRIAZOLE COMPOUNDS | DOW AGROSCIENCES LLC (US) | 2000-05-04 | — | — | WO | disclosed |
| US-6015826-A | INSECTICIDES, APHIDICIDES, AND MITICIDES | DOW AGROSCIENCES LLC | 2000-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020019370-A1 | Palladium catalyzed arylation, alkylation, deiodination or debromination | DDT, TYR, DDC | ACHE 60/4885CES2 393/4885CES1 504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.