Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP7 | P09237 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4036850 | 0.93 | ALDH1A1 (0.52) | ALDH1A1HPGDSMN1; SMN2MAPK1GAA | |
| SCHEMBL4035069 | 0.91 | GAA (0.53) | ALDH1A1HPGDSMN1; SMN2MAPK1GAA | |
| SCHEMBL4032496 | 0.88 | ALDH1A1 (0.51) | ALDH1A1HPGDSMN1; SMN2MAPK1GAA | |
| SCHEMBL4035404 | 0.84 | GAA (0.55) | ALDH1A1HPGDSMN1; SMN2MAPK1GAA | |
| SCHEMBL4038343 | 0.82 | GAA (0.57) | ALDH1A1HPGDSMN1; SMN2MAPK1GAA | |
| SCHEMBL4036852 | 0.80 | MMP1 (0.50) | ALDH1A1SMN1; SMN2GAALMNAHTT | |
| SCHEMBL4034935 | 0.79 | ALDH1A1 (0.51) | ALDH1A1HPGDSMN1; SMN2MAPK1GAA | |
| SCHEMBL4035075 | 0.77 | CHRM1 (0.40) | ALDH1A1HPGDSMN1; SMN2GAALMNA | |
| SCHEMBL4033651 | 0.77 | GAA (0.56) | ALDH1A1HPGDSMN1; SMN2MAPK1GAA | |
| SCHEMBL1384878 | 0.77 | ALDH1A1 (0.55) | ALDH1A1HPGDSMN1; SMN2MAPK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592389-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | Applied Research Systems ARS Holding N.V. (AN) | 2005-11-09 | — | — | EP | claimed |
| WO-2004071390-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-08-26 | — | — | WO | claimed |