Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6195598 | 0.86 | HTT (0.45) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6193627 | 0.84 | HTT (0.49) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6196253 | 0.81 | MAPT (0.43) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6198712 | 0.78 | KDM4E (0.41) | ALDH1A1HTTMEN1KMT2AMAPT | |
| SCHEMBL2118544 | 0.78 | SMN1; SMN2 (0.47) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6197894 | 0.75 | LMNA (0.53) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6196641 | 0.75 | HTT (0.35) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL29062603 | 0.74 | HTT (0.53) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6193376 | 0.74 | MAOB (0.45) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL10561186 | 0.72 | HTT (0.69) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0768302-B1 | Hydroxypyridinones | NOVARTIS AG (CH) | 2005-07-06 | — | — | EP | disclosed |
| US-5688815-A | COMPOUNDS FOR REMOVAL OF EXCESS IRON IN MAMMALS | CIBA GEIGY CORPORATION (US) | 1997-11-18 | — | — | US | disclosed |
| EP-0768302-A2 | Hydroxypyridinones | Novartis AG (CH) | 1997-04-16 | — | — | EP | disclosed |