Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 2/20 | 0.39 |
| ▸ | TACR2 | P21452 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6201334 | 0.99 | CCR5 (0.39) | CCR5TACR2KMT2AMEN1TSHR | |
| SCHEMBL6202591 | 0.98 | TACR2 (0.38) | CCR5TACR2KMT2AMEN1TSHR | |
| SCHEMBL6199169 | 0.96 | TACR2 (0.39) | CCR5TACR2KMT2AMEN1TSHR | |
| SCHEMBL6197643 | 0.89 | RECQL (0.43) | CCR5 | |
| SCHEMBL6196495 | 0.87 | CYP3A4 (0.38) | CCR5KMT2AMEN1TSHR | |
| SCHEMBL8113330 | 0.87 | TACR2 (0.35) | TACR2KMT2AMEN1TSHR | |
| SCHEMBL6201331 | 0.86 | KMT2A (0.38) | CCR5KMT2AMEN1TSHRNPSR1 | |
| SCHEMBL6202589 | 0.85 | KMT2A (0.37) | KMT2AMEN1TSHR | |
| SCHEMBL6199803 | 0.85 | SLC6A2 (0.41) | CCR5TACR2KMT2AMEN1 | |
| SCHEMBL6199797 | 0.84 | KMT2A (0.42) | CCR5KMT2AMEN1NPSR1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1048658-B1 | ALICYCLIC ACYLATED HETEROCYCLIC DERIVATIVES | SANKYO CO (JP) | 2005-06-15 | — | — | EP | disclosed |
| US-6288059-B1 | ANTIASTHMATIC, ANTIALLERGEN AGENTS; URINARY INCONTINENCE; NATURAL KILLER CELL RECEPTOR AND TACHYKININ ANTAGONISTS | SANKYO COMPANY, LIMITED (JP) | 2001-09-11 | — | — | US | disclosed |
| EP-1048658-A1 | ALICYCLIC ACYLATED HETEROCYCLIC DERIVATIVES | Sankyo Company Limited (JP) | 2000-11-02 | — | — | EP | disclosed |