Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6198535 | 0.79 | RAB9A (0.54) | KMT2AMEN1SMN1; SMN2HPGDRXFP1 | |
| SCHEMBL9145276 | 0.74 | CREBBP (0.55) | ERN1RORCKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6197205 | 0.73 | KCNH2 (0.44) | ERN1RORCKMT2AMAPTRAB9A | |
| SCHEMBL8204769 | 0.70 | CREBBP (0.66) | RORCKMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL5004961 | 0.70 | ALDH1A1 (0.62) | RORCKMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL10927299 | 0.70 | KMT2A (0.68) | KMT2AMEN1SMN1; SMN2HPGDMAPT | |
| SCHEMBL6469818 | 0.69 | KMT2A (0.67) | KMT2AMEN1SMN1; SMN2HPGDMAPT | |
| SCHEMBL6195538 | 0.69 | KMT2A (0.48) | KMT2AMEN1SMN1; SMN2HPGDRXFP1 | |
| SCHEMBL5347979 | 0.69 | MEN1 (0.60) | ERN1RORCKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL30532585 | 0.67 | KMT2A (0.56) | KMT2AMEN1SMN1; SMN2HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539168-A2 | TREATMENT OF NEUROPATHIC PAIN WITH 6H-PYRROLO(3,4-D)PYRIDAZINE COMPOUNDS | Merck & Co., Inc. (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004006836-A2 | TREATMENT OF NEUROPATHIC PAIN WITH 6H-PYRROLO[3,4-D]PYRIDAZINE COMPOUNDS | MERCK & CO., INC. (US) | 2004-01-22 | — | — | WO | disclosed |