Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.37 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.37 |
| ▸ | ITGAL | P20701 | 2/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.36 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.36 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6200064 | 0.88 | KMO (0.44) | KMOAKR1C3MAPTPRKDCKDM1A | |
| SCHEMBL6197601 | 0.81 | ITGAL (0.44) | KMOAKR1C3MAPTITGB2ICAM1 | |
| SCHEMBL6201628 | 0.80 | LGMN (0.47) | ITGB2ICAM1ITGALMEN1KMT2A | |
| SCHEMBL6311315 | 0.79 | ITGAL (0.42) | KMOAKR1C3ITGB2ICAM1ITGAL | |
| SCHEMBL6195506 | 0.78 | PNP (0.32) | MAPTPOLBNPC1RAB9AKDM4E | |
| SCHEMBL6318620 | 0.76 | ITGAL (0.43) | AKR1C3ITGB2ICAM1ITGALMEN1 | |
| SCHEMBL6317609 | 0.75 | ITGAL (0.43) | AKR1C3MAPTITGB2ICAM1ITGAL | |
| SCHEMBL6318224 | 0.75 | NOTUM (0.42) | AKR1C3MAPTITGB2ICAM1ITGAL | |
| SCHEMBL6917200 | 0.73 | ITGAL (0.42) | ITGB2ICAM1ITGALMEN1KMT2A | |
| SCHEMBL6530924 | 0.73 | THRB (0.43) | ITGB2ICAM1ITGALPOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140814-B1 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS | ABBOTT LAB (US) | 2005-05-25 | — | — | EP | disclosed |