Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 3/20 | 0.43 |
| ▸ | HRH1 | P35367 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 6/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5965702 | 0.87 | LMNA (0.43) | HRH2HRH1LMNAPOLBALDH1A1 | |
| SCHEMBL6096140 | 0.85 | KCNA5 (0.52) | HRH2HRH1LMNAPOLBP2RY12 | |
| SCHEMBL6095508 | 0.84 | HRH2 (0.41) | HRH2HRH1HRH3CYP3A4 | |
| SCHEMBL6093925 | 0.83 | HRH2 (0.41) | HRH2HRH1ALDH1A1HRH3 | |
| SCHEMBL7245277 | 0.83 | POLB (0.45) | HRH2HRH1LMNAPOLBALDH1A1 | |
| SCHEMBL6096585 | 0.82 | MGLL (0.42) | HRH2HRH1HRH3CYP2C9 | |
| SCHEMBL6095400 | 0.81 | HTR7 (0.42) | HRH2HRH1ALDH1A1HRH3 | |
| SCHEMBL6093832 | 0.81 | HRH2 (0.41) | HRH2HRH1KDM1AHRH3 | |
| SCHEMBL6093051 | 0.81 | HRH1 (0.49) | HRH2HRH1POLBALDH1A1HRH3 | |
| SCHEMBL6095012 | 0.80 | ALDH1A1 (0.53) | HRH2HRH1LMNAPOLBP2RY12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1360187-B1 | 3,7-DIAZABICYCLO(3.3.0)OCTANES AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2005-06-22 | — | — | EP | disclosed |
| EP-1360187-A1 | 3,7-DIAZABICYCLO(3.3.0)OCTANES AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2003-11-12 | — | — | EP | disclosed |
| WO-2002060902-A1 | 3,7-DIAZABICYCLO[3.3.0]OCTANES AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2002-08-08 | — | — | WO | disclosed |