Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
| ▸ | CDC25B | P30305 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5428355 | 0.83 | KDM4E (0.48) | MAPTKDM4EL3MBTL1NPC1RAB9A | |
| SCHEMBL6202961 | 0.83 | LMNA (0.39) | MAPTKDM4EL3MBTL1TDP1ALDH1A1 | |
| SCHEMBL6204597 | 0.79 | ALDH1A1 (0.39) | MAPTKDM4EL3MBTL1NPC1RAB9A | |
| SCHEMBL6204224 | 0.72 | TYMS (0.37) | MAPTKDM4EL3MBTL1RAB9ATDP1 | |
| SCHEMBL9257995 | 0.68 | KMT2A (0.45) | MAPTKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5414443 | 0.67 | HTR1B (0.38) | MAPTALDH1A1KMT2AMAPK1GAA | |
| SCHEMBL24039431 | 0.67 | DNMT1 (0.43) | MAPTL3MBTL1NPC1RAB9ATDP1 | |
| SCHEMBL6204660 | 0.67 | MAOB (0.36) | MAPTKDM4EL3MBTL1NPC1RAB9A | |
| SCHEMBL5418077 | 0.65 | ALDH1A1 (0.51) | MAPTKDM4EL3MBTL1NPC1RAB9A | |
| SCHEMBL4069381 | 0.65 | ALDH1A1 (0.57) | KDM4EL3MBTL1RAB9ATDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492795-B1 | 1- OR 3-THIA-BENZONAPHTHOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF | PLIVA ISTRAZIVACKI INST D O O (HR) | 2005-11-16 | — | — | EP | claimed |