Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 12/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4964735 | 0.87 | HSD11B1 (0.50) | HSD11B1MEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL452973 | 0.81 | HSD11B1 (0.77) | HSD11B1MEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL8152687 | 0.81 | HSD11B1 (0.66) | HSD11B1MEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL28391325 | 0.79 | HSD11B1 (1.00) | HSD11B1MEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL29944364 | 0.79 | HSD11B1 (1.00) | HSD11B1MEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL29609513 | 0.79 | HSD11B1 (0.74) | HSD11B1MEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL16660516 | 0.78 | HSD11B1 (0.73) | HSD11B1MEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL6278347 | 0.77 | HSD11B1 (0.71) | HSD11B1MEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL10931021 | 0.77 | HSD11B1 (1.00) | HSD11B1MEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL28888270 | 0.77 | HSD11B1 (1.00) | HSD11B1MEN1KMT2AALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |