Sugi Predict

Sugi Predict / Compounds / SCHEMBL6202982

SCHEMBL6202982

SCHEMBL6202982

Cc1ccc(C(=O)CS(=O)(=O)c2ccccc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ HSD11B1 P28845 11/20 1.00
▸ RECQL P46063 2/20 0.87
▸ ALDH1A1 P00352 4/20 0.69
▸ NPC1 O15118 2/20 0.69
▸ RAB9A P51151 2/20 0.69
▸ LMNA P02545 1/20 0.68
▸ PKM P14618 2/20 0.66
▸ MEN1 O00255 2/20 0.65
▸ KMT2A Q03164 2/20 0.65
▸ MAPT P10636 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2422002 0.93 RECQL (1.00) HSD11B1RECQLALDH1A1NPC1RAB9A
SCHEMBL29609963 0.92 RECQL (0.97) HSD11B1RECQLALDH1A1NPC1RAB9A
SCHEMBL29012562 0.91 HSD11B1 (0.83) HSD11B1RECQLALDH1A1NPC1RAB9A
SCHEMBL30209482 0.91 HSD11B1 (0.82) HSD11B1RECQLALDH1A1NPC1RAB9A
SCHEMBL10872654 0.89 RECQL (0.91) HSD11B1RECQLALDH1A1NPC1RAB9A
SCHEMBL452973 0.87 HSD11B1 (0.77) HSD11B1RECQLALDH1A1NPC1RAB9A
SCHEMBL30209483 0.87 HSD11B1 (0.76) HSD11B1RECQLALDH1A1NPC1RAB9A
SCHEMBL29609513 0.85 HSD11B1 (0.74) HSD11B1RECQLALDH1A1NPC1RAB9A
SCHEMBL16660516 0.84 HSD11B1 (0.73) HSD11B1RECQLALDH1A1NPC1RAB9A
SCHEMBL6199060 0.83 KMT2A (0.73) HSD11B1RECQLALDH1A1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114540321-B Preparation method of R-2-sulfonyl-1-phenylethanol derivative 沈阳药科大学 2024-04-02 — — CN disclosed
CN-110981676-B Method for preparing beta-ketosulfone compound through visible light mediated atoxic acid decarboxylation ketonization reaction 西南大学 2022-09-30 — — CN disclosed
CN-114540321-A Preparation method of R-2-sulfonyl-1-phenylethanol derivative 沈阳药科大学 2022-05-27 — — CN disclosed
CN-110981676-A Method for preparing β -ketosulfone compound through visible light mediated atoxic acid decarboxylation ketonization reaction 西南大学 2020-04-10 — — CN disclosed
US-20120196854-A1 PHARMACEUTICAL COMPOSITION COMPRISING AROMATIC HETEROCYCLIC COMPOUND KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-08-02 — — US disclosed
US-20050272036-A1 Ketones ASTRAZENECA AB (SE) 2005-12-08 — — US disclosed
EP-1549600-A1 KETONES AstraZeneca AB (SE) 2005-07-06 — — EP disclosed
WO-2004011410-A1 CHEMICAL COMPOUNDS ASTRAZENECA AB (SE) 2004-02-05 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120196854-A1 PHARMACEUTICAL COMPOSITION COMPRISING AROMATIC HETEROCYCLIC COMPOUND CYP2C18, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CYP2B6 HSD11B1 780/4885RECQL 40/4885ALDH1A1 2046/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.