Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 12/20 | 0.50 |
| ▸ | TP53 | P04637 | 6/20 | 0.50 |
| ▸ | POLB | P06746 | 5/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204336 | 0.85 | RAB9A (0.55) | RAB9ANPC1MAPTTP53POLB | |
| SCHEMBL6085124 | 0.79 | CASP3 (0.61) | RAB9ANPC1MAPTPOLBKDM4E | |
| SCHEMBL6204331 | 0.79 | RAB9A (0.59) | RAB9ANPC1MAPTTP53POLB | |
| SCHEMBL6198138 | 0.79 | MAPT (0.56) | RAB9ANPC1MAPTTP53POLB | |
| SCHEMBL6084882 | 0.78 | KDM4E (0.59) | RAB9ANPC1MAPTTP53POLB | |
| SCHEMBL6205323 | 0.78 | RAB9A (0.53) | RAB9ANPC1MAPTTP53POLB | |
| SCHEMBL6203401 | 0.77 | MAPT (0.54) | MAPTTP53POLBRXFP1KDM4E | |
| SCHEMBL6201851 | 0.77 | RAB9A (0.54) | RAB9ANPC1MAPTTP53POLB | |
| SCHEMBL13779246 | 0.76 | RAB9A (1.00) | RAB9ANPC1MAPTTP53POLB | |
| SCHEMBL6203549 | 0.74 | SMN1; SMN2 (0.52) | RAB9ANPC1MAPTTP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377589-B1 | OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2005-09-07 | — | — | EP | claimed |