Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | TP53 | P04637 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6087376 | 0.83 | PTGS2 (0.51) | MAPTTP53POLBRXFP1NPSR1 | |
| SCHEMBL6201851 | 0.79 | RAB9A (0.54) | MAPTTP53POLBRXFP1SMN1; SMN2 | |
| SCHEMBL6201345 | 0.77 | RAB9A (0.60) | MAPTTP53POLBRXFP1GAA | |
| SCHEMBL6203431 | 0.75 | GAA (0.60) | MAPTTP53POLBRXFP1GAA | |
| SCHEMBL6084412 | 0.75 | MAPT (0.71) | MAPTTP53POLBRXFP1GAA | |
| SCHEMBL6204331 | 0.74 | RAB9A (0.59) | MAPTTP53POLBRXFP1SMN1; SMN2 | |
| SCHEMBL23657588 | 0.74 | MAPT (0.84) | MAPTTP53POLBRXFP1GAA | |
| SCHEMBL6086017 | 0.74 | ALDH1A1 (0.58) | MAPTTP53POLBRXFP1GAA | |
| SCHEMBL6204336 | 0.74 | RAB9A (0.55) | MAPTTP53POLBRXFP1SMN1; SMN2 | |
| SCHEMBL6201586 | 0.73 | GLA (0.53) | MAPTTP53POLBGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377589-B1 | OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2005-09-07 | — | — | EP | claimed |