Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.57 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6325847 | 0.86 | MAPT (0.64) | KDM4ESMN1; SMN2MAPTGSK3BLMNA | |
| SCHEMBL11133530 | 0.85 | PKM (0.64) | KMT2AMEN1PLA2G4BALDH1A1KDM4E | |
| SCHEMBL26083579 | 0.85 | MEN1 (0.64) | KMT2AMEN1ALDH1A1MAPTPOLB | |
| SCHEMBL6202919 | 0.85 | MEN1 (0.61) | KMT2AMEN1PLA2G4BALDH1A1KDM4E | |
| SCHEMBL6321927 | 0.85 | ALOX5 (0.62) | KMT2AMEN1PLA2G4BALDH1A1SMN1; SMN2 | |
| SCHEMBL8064713 | 0.85 | NPC1 (0.62) | KMT2AMEN1PLA2G4BALDH1A1SMN1; SMN2 | |
| SCHEMBL31614562 | 0.82 | KMT2A (0.72) | KMT2AMEN1ALDH1A1KDM4EMAPT | |
| SCHEMBL3868073 | 0.80 | MAPT (0.63) | KDM4EMAPTLMNAL3MBTL1 | |
| SCHEMBL9316353 | 0.79 | CA1 (0.50) | KMT2AMEN1ALDH1A1KDM4EMAPT | |
| SCHEMBL28180210 | 0.79 | MAPT (0.56) | KMT2AMEN1ENPP2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| CN-1681763-A | Chemical compounds | ASTRAZENECA AB (SE) | 2005-10-12 | — | — | CN | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |