Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11133530 | 0.85 | PKM (0.64) | MEN1KMT2AALDH1A1PLA2G4BMAOB | |
| SCHEMBL6201392 | 0.85 | KMT2A (0.58) | MEN1KMT2AMAPTALDH1A1L3MBTL1 | |
| SCHEMBL26083579 | 0.85 | MEN1 (0.64) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL6321927 | 0.85 | ALOX5 (0.62) | MEN1KMT2AMAPTALDH1A1CYP2C19 | |
| SCHEMBL8064713 | 0.85 | NPC1 (0.62) | MEN1KMT2AMAPTALDH1A1CYP2C19 | |
| SCHEMBL16398971 | 0.82 | KMT2A (0.72) | MEN1KMT2AMAPTALDH1A1L3MBTL1 | |
| SCHEMBL1982760 | 0.81 | GSK3B (0.66) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL28180185 | 0.79 | MAPT (0.56) | MEN1KMT2AMAPTALDH1A1L3MBTL1 | |
| SCHEMBL1144017 | 0.78 | MAPT (0.64) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL29207098 | 0.78 | MAPT (0.64) | MEN1KMT2AMAPTALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| CN-1681763-A | Chemical compounds | ASTRAZENECA AB (SE) | 2005-10-12 | — | — | CN | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |