Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 5/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | ATM | Q13315 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TYMS | P04818 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6086038 | 0.85 | GLA (0.53) | GLAPTGS2MAPTTP53LMNA | |
| SCHEMBL6203401 | 0.73 | MAPT (0.54) | MAPTTP53POLBKDM4EALDH1A1 | |
| SCHEMBL6201345 | 0.73 | RAB9A (0.60) | MAPTTP53HPGDPOLBKDM4E | |
| SCHEMBL6204336 | 0.71 | RAB9A (0.55) | MAPTTP53LMNAHPGDPOLB | |
| SCHEMBL6204331 | 0.70 | RAB9A (0.59) | MAPTTP53LMNAHPGDPOLB | |
| SCHEMBL6085407 | 0.70 | NPC1 (0.51) | MAPTTP53LMNAHPGDPOLB | |
| SCHEMBL6198138 | 0.69 | MAPT (0.56) | MAPTTP53LMNAHPGDPOLB | |
| SCHEMBL6085175 | 0.69 | CETP (0.47) | MAPTTP53LMNAHPGDATM | |
| SCHEMBL3634973 | 0.69 | GHSR (0.88) | GLAMAPTTP53LMNAHPGD | |
| SCHEMBL6201851 | 0.68 | RAB9A (0.54) | MAPTTP53LMNAHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377589-B1 | OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2005-09-07 | — | — | EP | claimed |