Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.51 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.48 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.45 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.44 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL496975 | 0.79 | ELANE (0.70) | ELANESLC22A12TFPI2ASAH1KMO | |
| SCHEMBL29238955 | 0.78 | ELANE (0.68) | ELANESLC22A12TFPI2ASAH1KMO | |
| SCHEMBL260982 | 0.77 | SLC22A12 (0.54) | ELANESLC22A12TFPI2ASAH1KMO | |
| Hydrochloric Acid SCHEMBL30581596 | 0.75 | SLC22A12 (0.53) | ELANESLC22A12TFPI2ASAH1KMO | |
| SCHEMBL4423022 | 0.75 | SLC22A12 (0.55) | ELANESLC22A12TFPI2ASAH1KMO | |
| SCHEMBL2025416 | 0.72 | SLC22A12 (0.56) | ELANESLC22A12TFPI2ASAH1KMO | |
| SCHEMBL1087434 | 0.72 | CHEK1 (0.60) | ELANESLC22A12TFPI2ASAH1KMO | |
| Indazole Carboxamide SCHEMBL42505 | 0.72 | SLC22A12 (0.53) | ELANESLC22A12TFPI2ASAH1KMO | |
| SCHEMBL300192 | 0.71 | TFPI2 (0.49) | ELANESLC22A12TFPI2ASAH1KMO | |
| Indazole Carboxamide SCHEMBL15638369 | 0.70 | SLC22A12 (0.51) | ELANESLC22A12TFPI2ASAH1KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444207-A2 | SUBSTITUTED PYRAZOLYL-COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2004-08-11 | — | — | EP | claimed |
| WO-2003024935-A2 | SUBSTITUTED PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2003-03-27 | — | — | WO | claimed |
| EP-1501805-A1 | SUBSTITUTED PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003095430-A1 | SUBSTITUTED PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2003-11-20 | — | — | WO | disclosed |