Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 5/20 | 0.70 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | F2 | P00734 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | MGAM | O43451 | 1/20 | 0.51 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | SI | P14410 | 1/20 | 0.51 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.51 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.49 |
| ▸ | KMO | O15229 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29238955 | 0.98 | ELANE (0.68) | ELANESLC22A12KMT2AF2HPGD | |
| SCHEMBL260982 | 0.83 | SLC22A12 (0.54) | ELANESLC22A12KMT2ARAB9ATFPI2 | |
| Hydrochloric Acid SCHEMBL30581596 | 0.81 | SLC22A12 (0.53) | ELANESLC22A12KMT2ARAB9ATFPI2 | |
| SCHEMBL5433163 | 0.81 | ELANE (0.53) | ELANESLC22A12KMT2AF2HPGD | |
| SCHEMBL4423022 | 0.81 | SLC22A12 (0.55) | ELANESLC22A12KMT2ARAB9ATFPI2 | |
| SCHEMBL29898250 | 0.80 | SLC22A12 (1.00) | ELANESLC22A12MGAMAMY1AGAA | |
| SCHEMBL6201897 | 0.79 | ELANE (0.51) | ELANESLC22A12KMT2AF2HPGD | |
| SCHEMBL11311967 | 0.78 | PLA2G10 (0.55) | ELANESLC22A12KMT2AF2HPGD | |
| Indazole Carboxamide SCHEMBL42505 | 0.78 | SLC22A12 (0.53) | ELANESLC22A12KMT2ARAB9ATFPI2 | |
| SCHEMBL1087434 | 0.78 | CHEK1 (0.60) | ELANESLC22A12KMT2ARAB9ATFPI2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116606246-A | Silver complex antibacterial agent with aromatic amide structure-containing nitrogen heterocyclic derivative as ligand, and preparation method and application thereof | 烟台哈尔滨工程大学研究院 | 2023-08-18 | — | — | CN | disclosed |
| US-8198298-B2 | Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors | PFIZER ITALIA S.R.L. (IT) | 2012-06-12 | — | — | US | disclosed |
| US-8106069-B2 | Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2012-01-31 | — | — | US | disclosed |
| US-20110136857-A1 | PYRROLE[2,3-B]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS | PFIZER ITALIA S.R.L. (IT) | 2011-06-09 | — | — | US | disclosed |
| US-7888508-B2 | 3-(carboxy or carbamoyl)-5-amino-1H-pyrrolo(2,3-b)pyridines; cancer, Alzheimer's disease, viral infections, autoimmune diseases and neurodegenerative disorders; chemical libraries of these compounds | PFIZER ITALIA S.R.L. (IT) | 2011-02-15 | — | — | US | disclosed |
| US-20100210476-A1 | Pyrrolo[2,3-b]Pyridine Derivatives Active as Kinase Inhibitors and Pharmaceutical Compositions Comprising Them | PFIZER ITALIA S.R.L. (IT) | 2010-08-19 | — | — | US | disclosed |
| US-7728140-B2 | Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2010-06-01 | — | — | US | disclosed |
| EP-1701956-B1 | PYRROLO[2,3-B]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PFIZER ITALIA SRL (IT) | 2010-02-24 | — | — | EP | disclosed |
| EP-1704147-B1 | PYRROLO[2,3-b] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION COMPRISING THEM | PFIZER ITALIA SRL (IT) | 2009-11-04 | — | — | EP | disclosed |
| CN-100396678-C | Synthesis and use of indole analogues of 1-benzyl-3- (5 '-hydroxymethyl-2' -furyl) indazole | IND TECH RES INST (CN) | 2008-06-25 | — | — | CN | disclosed |
| US-7176230-B2 | Synthesis of indole analogs of 1-benzyl-3-(5′-hydroxymethyl-2′-furyl) indazole (YC-1) as anti-platelet agents | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2007-02-13 | — | — | US | disclosed |
| EP-1701956-A1 | PYRROLO[2,3-B]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pfizer Italia S.r.l. (IT) | 2006-09-20 | — | — | EP | disclosed |
| CN-1827616-A | Synthesis and use of indole analogues of 1-benzyl-3- (5 '-hydroxymethyl-2' -furyl) indazole | IND TECH RES INST (CN) | 2006-09-06 | — | — | CN | disclosed |
| US-20060106041-A1 | Synthesis of indole analogs of 1-benzyl-3-(5'-hydroxymethy 1-2' -furyl) indazole (YC-1) as anti-platelet agents | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2006-05-18 | — | — | US | disclosed |
| US-20050256151-A1 | Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PHARMACIA ITALIA S.P.A. (IT) | 2005-11-17 | — | — | US | disclosed |
| US-20050209269-A1 | Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PHARMACIA ITALIA S.P.A. (IT) | 2005-09-22 | — | — | US | disclosed |
| WO-2005063746-A1 | PYRROLO[2,3-b]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PFIZER ITALIA S.R.L. (IT) | 2005-07-14 | — | — | WO | disclosed |
| EP-0135781-B1 | 3-(PIPERIDINYL)- AND 3-(PYRROLIDINYL)-1H-INDAZOLES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS A MEDICAMENT | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-10-11 | — | — | EP | disclosed |
| EP-0192935-A1 | 3-(piperidinyl)-1H-indazoles a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-09-03 | — | — | EP | disclosed |
| EP-0135781-A1 | 3-(Piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles, a process for their preparation and their use as a medicament | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1985-04-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210476-A1 | Pyrrolo[2,3-b]Pyridine Derivatives Active as Kinase Inhibitors and Pharmaceutical Compositions Comprising Them | MAP3K6, MAP3K3, MAP3K1 | ELANE 4747/4885SLC22A12 4847/4885KMT2A 1717/4885 |
| US-20060106041-A1 | Synthesis of indole analogs of 1-benzyl-3-(5'-hydroxymethy 1-2' -furyl) indazole (YC-1) as anti-platelet agents | PFKP, HMOX1, TPH1 | ELANE 2497/4885SLC22A12 4729/4885KMT2A 2910/4885 |
| US-20050256151-A1 | Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K6, MAP3K3, MAP3K1 | ELANE 4801/4885SLC22A12 4864/4885KMT2A 1599/4885 |
| US-20110136857-A1 | PYRROLE[2,3-B]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS | MAP3K6, MAP3K3, MAP3K15 | ELANE 4734/4885SLC22A12 4850/4885KMT2A 1503/4885 |
| US-20050209269-A1 | Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K6, MAP3K3, MAP3K1 | ELANE 4801/4885SLC22A12 4864/4885KMT2A 1599/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.