Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | NCF1 | P14598 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5238095 | 0.91 | ALDH1A1 (0.57) | ALDH1A1MAPTKCNJ1SMN1; SMN2LMNA | |
| SCHEMBL6704152 | 0.88 | L3MBTL1 (0.53) | ALDH1A1MAPTPOLBKMT2AMEN1 | |
| SCHEMBL546450 | 0.84 | ALDH1A1 (0.64) | ALDH1A1MAPTKCNJ1SMN1; SMN2LMNA | |
| SCHEMBL30061320 | 0.84 | ALDH1A1 (0.64) | ALDH1A1MAPTKCNJ1SMN1; SMN2LMNA | |
| SCHEMBL21600747 | 0.83 | ALDH1A1 (0.63) | ALDH1A1MAPTKCNJ1SMN1; SMN2LMNA | |
| SCHEMBL6609562 | 0.80 | ALDH1A1 (0.59) | ALDH1A1MAPTKCNJ1SMN1; SMN2LMNA | |
| SCHEMBL29710198 | 0.80 | ALDH1A1 (0.59) | ALDH1A1MAPTKCNJ1SMN1; SMN2LMNA | |
| SCHEMBL27087824 | 0.80 | ALDH1A1 (0.68) | ALDH1A1MAPTKCNJ1SMN1; SMN2LMNA | |
| SCHEMBL27985029 | 0.80 | CTSB (0.60) | ALDH1A1MAPTKCNJ1SMN1; SMN2LMNA | |
| SCHEMBL16054038 | 0.80 | ALDH1A1 (0.59) | ALDH1A1MAPTKCNJ1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1507776-A1 | 2-OXO-1,3,4-TRIHYDROQUINAZOLINYL DERIVATIVES FOR THE TREATMENT OF CELL PROLIFERATION-RELATED DISORDERS | Amgen Inc. (US) | 2005-02-23 | — | — | EP | disclosed |
| WO-2003101985-A1 | 2-OXO-1,3,4-TRIHYDROQUINAZOLINYL DERIVATIVES FOR THE TREATMENT OF CELL PROLIFERATION-RELATED DISORDERS | AMGEN INC. (US) | 2003-12-11 | — | — | WO | disclosed |